Types of Tolerance

Generally, for design purposes, wth this type of tolerance, nominal thickness = 0.50 in. can be used for calculations. 

It must also be noted that an inducer may enhance not only the metabolism of other drugs but also its own metabolism. Thus, continued use of some drugs may result in a pharmacokinetic type of tolerance—progressively reduced therapeutic effectiveness due to enhancement of their own metabolism. 

Types of Tolerance Explanations of Tolerance Behavioral Pharmacology Reinforcement and Punishment Operant Principles and Drug Dependence Drug Discrimination Conflict Paradigm... 

The third type of tolerance invoh cs a behavioral adjustment by the subject and is called behavioral or learned tolerance. For example, an individual who has had considerable experience with the effects of alcohol on motor coordination may learn to compensate for his or her intoxication by walking slowly or with a lower center of gravity to keep from falling—e en if he or she is quite drunk (for example, Vogel-Sprott, 1992). Other examples of learned or behavioral tolerance are discussed later. 

Tolerance is an extremely important concept in understanding human drug-use patterns. There are several different types of tolerance. 

The type of tolerance shown in Figure 8 is referred to as a process tolerance (5). It is not as restrictive as a statistical tolerance, which assumes perfectly centered processes. It is more restrictive than a worst-case tolerance, which makes no assumptions about the average. Process tolerances like the one in Figure 8 represents middle ground between statistical tolerances and worst-case tolerances. 

Input Type of tolerance Target Tolerance for values Tolerance for average... 

Tolerance specification usually involves the identification of the features to be toleranced and the required datum features, the determination of the types of tolerances needed and material conditions, and, finally, the assignment of the tolerance values as per functional requirement. To do so, several approaches based on graphs and/or rules are continuously being developed, tested, and implemented in industry ... 

The other three types of tolerance (pharmacokinetic, pharmacodynamic, and learned) are clubbed as acquired tolerance. In contrast to innate tolerance, this type of tolerance develops with continued opioid administration, and thus represents true tolerance rather than genetically mediated lack of sensitivity to opioids. 

A considerable number of stress protein inducers, such as cadmium, ethanol, and sodium arsenite, are as effective as heat in conditioning the cell to become thermotolerant. This type of tolerance, where the inducing and stress stimulus are different, is termed cross-tolerance. Induction of cross-... 

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