Types of Genetic Variants

With the completion of the human genome project, efforts shifted to the identification of genetic variation across the genome. Currently, there are several efforts addressing genetic variations and various databases and publications that report the 

An alternative approach to the analysis of individual candidate gene variants is to use as the unit of analysis gene haplotypes instead of single SNPs. This overrides the need of knowledge on the functional consequences of genetic variants. Several studies of linkage disequilibrium across the human genome have shown that most 

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Chapter 4—The Impact of Genetic Variation on Drug Discovery and Development Barnes describes the various types of genetic variants (e.g., polymorphisms) and explains how these play a key role in target identification and validation. He also covers the tools and databases available to researchers studying genetic variants. 

GENOMIC BASIS OF PHARMACOGENETICS Types of Genetic Variants... 

The three types of genetic variants used to probe the biological properties of VSV that lead to inhibition of host cell protein synthesis are deletion mutants (defective-interfering virus), temperature-sensitive (ts) mutants, and nonconditional mutants. 

There are reports that still other types of cholinesterase variants can be identified by electrophoretic studies. In most cases, it has not been determined whether these are genetically determined variants or acquired variants. Most of these variants have been detected by electrophoresis in a sieving gel such as starch or polyacrylamide. However, it must always be kept in mind that two new slow-migrating bands are detectable after performing two-dimensional electrophoresis on serum that has been stored (H6). The first band appears after storage for about 10 days at either 4°C... 

Different types of symmetry are appropriate for proteins localized in different environments. In assemblies with intermediate numbers of protomers, the symmetry is often reduced by the inclusion of genetic variants, in order to restrict the tendency to polymerize. Finally, symmetry tends to be preserved when subunits change conformation, giving rise to the phenomenon of cooperativity, which is often cmcial to function. 

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