Type-II Diabetes Mellitus

Familial hypertriacylglycerolemia (type IV) Overproduction of VLDL often associated with glucose intolerance and hyperinsulinemia. Cholesterol levels rise with the VLDL concentration. LDL and HDL tend to be subnormal. This type of pattern is commonly associated with coronary heart disease, type II diabetes mellitus, obesity, alcoholism, and administration of progestational hormones. 

Type II diabetes mellitus since age 48. He admits that his diet prevents his diabetes from being well controlled. 

Recurrent intestinal strictures, intestinal obstructions, type II diabetes mellitus... 

I. Magnusson, D. L. Rothman, L. D. Katz, R. G. Shulman, and G. I. Shulman, Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study, J. Clin. Invest. 90 1323 (1992). 

Treatment of Maturity-Onset (Type II) Diabetes Mellitus... 

In the case of NIDDM (maturity onset or type II diabetes mellitus), insulin is present in the blood at normal (or even elevated) levels, but fails to promote any of its characteristic effects. A number of factors can contribute to such insulin resistance, including ... 

TABLE 67.1 Features of Type I and Type II Diabetes Mellitus... 

The sulfonylureas are ineffective for the management of type I and severe type II diabetes mellitus, since the number of viable -cells in these forms of diabetes is small. Severely obese diabetics often respond poorly to the sulfonylureas, possibly because of the insulin resistance that often accompanies obesity. 

A 60-year-old male alcoholic treated for type II diabetes mellitus develops lactic acidosis. Which of the following oral hypoglycemic agents might cause this adverse effect ... 

It is indicated in the management of type II diabetes mellitus in patients who are not responding to diet and exercise. 

Scorpiglione N, Belfiglio M, Carinci F, Cavaliere D, De Curtis A, Franciosi M, Mari E, Sacco M, Tognoni G, Nicolucci A. The effectiveness, safety and epidemiology of the use of acarbose in the treatment of patients with type II diabetes mellitus. A model of medicine-based evidence. Eur J Clin Pharmacol 1999 55(4) 239-49. 

Chung M, Kourides I, Canovatchel W, Sutfin T, Messig M, Chaiken RL. Pharmacokinetics and pharmacodynamics of extended-release glipizide GITS compared with immediate-release glipizide in patients with type II diabetes mellitus. J Clin Pharmacol 2002 42(6) 651-7. 

A 51-year-old woman with an 18-year history of type II diabetes mellitus developed glucose dysregulation with persistent hyperglycemia within 3 weeks of starting treatment with olanzapine, in the absence of weight gain (863). 

Mouse Models of type II Diabetes Mellitus in Drag Discovery... 

Key words Type II diabetes mellitus, drug discovery, glucose tolerance test, insulin tolerance test,... 

Tiggelaar JM. 1987. Protocols for the treatment of essential hypertension and type II diabetes mellitus by pharmacists in ambulatory care clinics. Drug Intell Clin Pharm 21 521. 

Schwartz, S., Raskin, P., Fonseca, V. et al. (1998). Effect of Troglitazone in Insulin-Treated Patients with Type II Diabetes Mellitus. N. Engl.J. Med. 338, 861-866. 

Duration of non-insulin-dependent (type II) diabetes mellitus, sufficiency of endogenous insulin, and recommended sequence of therapy. 

Bagchi, M., Palaniswami, N., Desai, H., Felicetta, J., and Brown, T. R. (1988). Decreased thyroidal response to thyrotropin in type II diabetes mellitus. Metabolism 37,669-671. 

Biguanides are used as an oral drug for the management of mild to moderately severe, noninsulin-depend-ent (type II) diabetes mellitus in obese patients who are usually above 40 years of age. It is important that for the administration of this drug the disease should have adult onset. 

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