Two-dimensional spectroscopy,

Two-dimensional spectroscopy has two broad classes of experiments (a) 2D /-resolved spectra (Mtlller et ai, 1975 Aue et ai, 1976), in which no coherence transfer or mixing process normally occurs, and chemical shift and coupling constant frequencies are spread along two different axes. 

Exponential decay often occurs in measurements of diffusion and spin-relaxation and both properties are sensitive probes of the electronic and molecular structure and of the dynamics. Such experiments and analysis of the decay as a spectrum of 7i or D, etc., are an analog of the one-dimensional Fourier spectroscopy in that the signal is measured as a function of one variable. The recent development of an efficient algorithm for two-dimensional Laplace inversion enables the two-dimensional spectroscopy using decaying functions to be made. These experiments are analogous to two-dimensional Fourier spectroscopy. 

Two-dimensional spectroscopy is a rather novel concept, and a powerful tool in analysing spectra. The advantages of generalised 2D correlation spectroscopy are ... 

In 1993, Noda has introduced generalized two-dimensional spectroscopy that can be applied to a lot of spectroscopic measurements [1], A simple and efficient computational technique to obtain the 2D correlation spectra is to use a form of discrete... 

Although the first NMR spectra of deuterated proteins were published already in 1968, the deuteration was mainly employed for the purpose of simplifying one-dimensional proton spectra.53,54 Later in the 1980s, LeMaster and co-workers employed random fractional deuteration for the assignment of thioredoxin using homonuclear two-dimensional spectroscopy.55 However, it was realized that deuteration significantly improves the spectral quality of homonuclear multidimensional NMR experiments. 

H. Friebohn, Basic One- and Two-Dimensional Spectroscopy, 3" Edn., Wiley-VCH, Weinheim, 1998. 

Brixner T, Stenger J, Vaswani HM, Cho M, Blankenship RE, Fleming GR (2005) Two-dimensional spectroscopy of electronic couplings in photosynthesis. Nature 434 625... 

We have chosen to dedicate a full chapter to the nuclear Overhauser effect [1,2] (NOE) because its comprehension is of fundamental importance in dealing with nuclear relaxation [3,4], Especially in paramagnetic compounds, it still represents a most powerful technique to detect dipolar connectivities finally it allows the comprehension of two-dimensional spectroscopies based on dipolar coupling. The NOE is the fractional variation of the intensity of a signal when another signal is selectively saturated. 

VES is a type of coherent infrared two-dimensional spectroscopy. The two dimensions are frequency and time. The VES results demonstrate the potential of using VES to enhance vibrational spectra and potentially... 

Aue WP, Bartoldi E, Ernst RR. Two-dimensional spectroscopy applications to nuclear magnetic resonance. J Chem Phys 1976 64 2229-2246. 

Steffen T, Duppen K. Femtosecond two-dimensional spectroscopy of molecular motion in liquids. Phys Rev Lett 1996 76 1224-1227. 

Most demonstrations of J-resolved two-dimensional spectroscopy have been heteronuclear, using experiments, and the... 

FIG. 19. Schematic representation of a simple (non-spin echo) form of two-dimensional spectroscopy, r, is the evolution, i2 the detection period. From ref. 157. 

Clore GM, et al. Analysis of the backbone dynamics of interleukin-1 beta using two-dimensional inverse detected heteronuclear 15N-1H NMR spectroscopy. Biochemistry 1990 29 7387-7401. Aue WP, Bartholdi E, Ernst RR. Two-dimensional spectroscopy. Application to nuclear magnetic resonance. J. Chem. Phys. 1976 64 p. 2229-2246. 

WP Aue, E Bartholdi, RR Ernst. Two-dimensional spectroscopy. Application to nuclear magnetic Resonance. J Chem Phys 64 2229-2246, 1976. 

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