Tumour metastasis

Hunter K. Host genetics influence tumour metastasis. Nat Rev Cancer 2006 6 141-146. 

SialylT [2] hypersialylation found in oncogenic transformation tumour metastasis invasion... 

Kaufmann, A. M., Lichtner, R. B., Schirrmacher, V. and Khazaie, K. (1996). Induction of apoptosis by EGF receptor in rat mammary adenocarcinoma cells coincides with enhanced spontaneous tumour metastasis. Oncogene 13, 2349-2358. 

Perissin, L., Zorzet, S., Piccini, P, Rapozzi, V. and Giraldi, T. (1989). Corticosterone does not mediate the effects of stress on tumour metastasis. Pharmacol. Res. 21, 461 62. 

Mandriota, S. J., L. Jussila, M. Jeltsch, A. Compagni, D. Baetens, R. Prevo, S. Banerji, J. Huarte, R. Montesano, D. G. Jackson, L. Orci, K. Alitalo, G. Christofori, and M. S. Pepper. 2001. Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis. EM BO J 20 672 682. 

Adhesion of circulating tumour cells to microvascu-lar endothelium plays an important role in tumour metastasis to distant organs. 

Suga T, Yoshihama T, Tsuchiya Y, Shiio T, Maeda YY, Chihara G (1989) Prevention of tumour metastasis and recurrence of DBA/2.MC.CS-1, DBA/2.MC.CS-T fibrosarcoma, MH-134 hepatoma, and other murine tumours using lentinan. Int J Immunotherapy 5 187-193... 

Matthews, H., Tyndall, J., and Kelso, M.J. (2011) Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride an orally active anti-cancer drug waiting for its call-of-duty International Journal of Cancer, 129, 2051-2061. 

Okada K, Sakusabe N, Kobayashi A, Hoshi N, Sato K. Prevention of lung metastasis by intra-tumoural injection of Cepharanthin and staphylococcal enterotoxin B in transplantable rat osteosarcoma. Jpn J Cancer Res 1999 90 928-933. 

F3. Fidler, I. J., Selection of successive tumour lines for metastasis. Nature (London) New Biol. 242, 148-149(1973). 

Benign tnmonrs are nsnally only a problem when they impair the fnnction of organs or canse metabolic stress. They can be removed by snrgery or radiation therapy. Malignant tnmonrs are mnch more of a problem, since the cells can escape from the primary tnmonr to other sites in the body, where they settle and develop into secondary tumours (metastases). Then, chemotherapy is the only treatment available. The process is known as metastasis. 

A transmissible sarcoma of the chicken has been under observation in this laboratory for the past fourteen months, and it has assumed of late a special interest because of its extreme malignancy and a tendency to widespread metastasis. In a careful study of the growth, tests have been made to determine whether it can be transmitted by a filtrate free of the tumour cells. Attempts to so transmit rat, mouse, and dog tumours have never succeeded and it was supposed that the sarcoma of the fowl would not differ from them in this regard, since it is a typical neoplasm. On the contrary, small quantities of a cell-free filtrate have sufficed to transmit the growth to susceptible fowls. 

Carol Box Tumour Biology and Metastasis, Cancer Research UK Cancer Therapeutics Unit, Division of Cancer Therapeutics, McElwain Laboratories, The Institute of Cancer Research, Surrey, UK... 

R. Hoffman, Green fluorescent protein imaging of tumour growth, metastasis, and angiogenesis in mouse models. Lancet Oncol. 3 (2002) 546-556. 

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