Tumour angiogenesis

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Although the downstream events hy which cannabinoids exert their antitumoural action are not completely unravelled, there is certain evidence for the implication of at least three mechanisms tumour cell apoptosis, tumour cell growth arrest, and inhibition of tumour angiogenesis. 

Carmeliet P, Dor Y, Herbert JM, et al. (1998) Role of HIF-1 alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394 485 490... 

Okaji Y, Tsuno N H, Salto S, et al. (2006). Vaccines targeting tumour angiogenesis— A novel strategy for cancer immunotherapy. Euro. J. Surgical Oncology. In Press, Corrected Proof. 

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The involvement of pericytes in physiological or tumour angiogenesis is a matter of debate. Papoutsi et al. (2000) studied the expression of pericyte, smooth muscle cell and matrix markers in experimental tumours of the mammary ductal adenoma MDA-MB231 cell line grown on chick or quail chorioallantoic membrane. Pericyte-like cells may be attracted by MDA-MB231 cells during tumour angiogenesis but failed to interact properly with endothelial cells in the tumour environment (Lauer et al. 2000). 

Copper ions required for tumour angiogenesis may be chelated in two tridentate, hydrazone-copper complexes, pyridine-2-carboxaldehyde-2 -pyridylhydrazonato-Cu(II) and salicylaldehydeben-zoyl-hydrazonato-Cu(II), which inhibited the growth of an implanted methylcholanthrene-induced fibrosarcoma (MCA 1511) in Balb/C mice (PiCKART et al. 1983). 

Hirst DG, Flitney FW (1997) The physiological importance and therapeutic potential of nitric oxide in the tumour-associated vasculature. In Bicknell R, Lewis CE, Ferrara N (eds) Tumour angiogenesis. Oxford University Press, Oxford, pp 153-167... 

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