Tumor microvasculature

Tumor Microvasculature as a Therapeutic Target During Radiotherapy... 

The dorsal skin fold window model allows direct observation of tumor microvasculature (11). This model also permits longitudinal assessment of the tumor vascular response to therapy. An accurate systematic measurement of tumor blood vessels in the window model is the linear summation of blood vessels using Optimas software. This approach corrects for vascular dilation and hemorrhage. Quantification of red... 

Tumor Microvasculature and Microenvironment Therapeutic Targets for Inhibition of Tumor Angiogenesis and Metastasis... 

Fukumura D, Jain RK. Tumor microvasculature and microenvironment targets for anti-angiogenesis and normalization. Microvasc Res 2007 74 72-84. 

Fig. 4.2. Flow chart describing the mechanisms responsible for the increase in geometric and viscous resistance to flow caused by structural and functional abnormalities of the tumor microvasculature, which lead to a hostile tumor microenvironment...

As already described in Sects. 15.2 and 15.3, immunotherapy is heavily hampered by the morphologically aberrant tumor microvasculature and increased interstitial fluid pressure, which can impede the delivery of cytokines and monoclonal antibodies and can prevent immigration of immune effector cells into the established tumor parenchyma. 

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