Tumor blood vessels targeting

We have previously developed an in vivo selection method in which peptides that home to specific vascular beds are selected after intravenous administration of a phage display random peptide library [5]. This strategy revealed a vascular address system that allows tissue-specific targeting of normal blood vessels [6-8] and angiogenesis-related targeting of tumor blood vessels [3, 6, 9-12]. While the biologi-... 

Targeting Tumor Blood Vessels With a Toxin Conjugate... 

Fabbrini M, Trachsel E, Soldani P, Bindi S, Alessi P, Bracci L, et al. Selective occlusion of tumor blood vessels by targeted delivery of an antibody-photosensitizer conjugate. Int J Cancer 2006 118 1805-1813. 

Maeda, H. The tumor blood vessel as an ideal target for macromolecular anticancer agents. J. Control. Release 1992, 19, 315-324. 

One of the most commonly used terms to explain drug targeting is the EPR effect. The porosity and pore size of tumor blood vessels has been amenable to nanocarriers for tumor-targeting therapy, imaging, and diagnosis. The porosity facilitates the supply of adequate nutrients to the developing area in tumors. When tumor growth is inhibited or when the tumor size is decreased by any... 

Hallahan D, Geng L, Qu S, Scarfone C, Giorgio T, Donnelly E et al. Integrin-mediated targeting of drug delivery to irradiated tumor blood vessels. Cancer Cell 2003 3 63-74. 

PEGylated liposomes targeted with anti-GD2 and with NGR-peptides specifically binding with the tumor vasculature, produced an improved therapeutic effect by acting on both tumor cells and tumor blood vessels. 

---