Tubulin-binding agents

Colchicine as allelochemical is peculiar to Colchicium genus and when it is released by the cell-donor, can interact with the cell-acceptor. This alkaloid is also known as the tubulin-binding agent, which blocks its polymerization in microtubes (Roshchina, 2005a b). This alkaloid penetrates the cell-acceptor and induces the fluorescence of some cellular compartment (Fig. 9). The own emission of pure compound is 300 times less. 

Tubulin-Binding Agents Synthetic, Structural and Mechanistic Insights... 

NMR-Derived Bioactive Conformation of Tubulin-Binding Agents... 

Invention Significance Stilbenoid tubulin-binding agents structurally... 

Tubulin-binding agents prepared by Pinney (4) consisting of dihydronaphthalene derivatives, (IV), exhibited potent tumor cell cytotoxicity by inhibiting the polymerization of a,(3-tubulin heterodimers into the microtubule structures and were used in the treatment of proliferation diseases. 

Tubulin binding agents interfere with the dynamic instability of microtubules and thereby arrest mitotic cells in the M-phase of the cell division cycle, finally leading to induction of apoptosis. Most, if not all, tubulin inhibitors bind within fl-tubulin to distinct epitopes. They are... 

Dumontet C. Mechanism of action and resistance to tubulin binding agents. Expert Opinion Inves Drugs 2000 9 779-788. 

Figure 8.5 Representative tubulin binding agents and general structure of the synthesized benzils 4 [56]. (Reproduced with permission from Elsevier.)...

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