Tuberculosis minocycline

Not all mycobacterial infections are caused by M. tuberculosis or M. leprae. These atypical mycobacteria require treatment with secondary medications as well as other chemotherapeutic agents. For example, M. marinum causes skin granulomas, and effective drugs in the treatment of infection are rifampin or minocycline. Mycobacterium fortuitum causes skin ulcers and the medications recommended for treatment are ethambutol, cycloserine, and rifampin in combination with amikacin. 

Several clinically isolated strains of Neisseria meningitidis proved sensitive to minocycline—and to doxycycline--at <0.78 mcg/ml, which suggests consideration of these antibiotics as candidates for prophylaxis in meningococcal outbreaks. Minocycline at 100 mg/kg/day in a drug diet is effective against tuberculosis 11375 infections in mice while doxycycline and tetracycline are inactive at UOO and 6OO mg/kg respectively ethambutol is effective at 50 mg/kg. 

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