TSH

Fig. 3. Fluman LH, FSH, and TSH a suburnt [69431-84-1]. Amino acid numbering is relative to maximum homology between species (48). Note the 4 amino acid deletion in human a suburnt between positions 6 and 9. Consensus glycosylation sites are at Asn-56 and 82. GHO = carbohydrate chain.

One glycosylation site exists on the P suburhts of human LH [53664-53-2 and TSH [64365-92-OJ ie, Asn-30 (Fig. 4). In some species, Asn-13 of LH-P is glycosylated (48). FSH-P suburnt [58857-12-8] is glycosylated at two sites, Asn-13 and 30. Based on interactions of synthetic peptides with the LH receptor, loops formed by P93—100 and P38—57 may be essential for hormone bioactivity (48). Highly conserved sequences between residues 31—37 have been implicated in the formation of the a—P suburnt dimer (48), which is absolutely necessary for the expression of bioactivity. 

Fig. 4. Human LH, FSH, and TSH P subunits. Amino acid numbeiing is relative to maximum homology between the three subunits. Consensus...

Thyroid-stimulating hormone can be used clinically to test thyroid function but has not found practical apphcation in the treatment of human thyroid insufficiency. Direct replacement therapy with thyroid hormone is easy and effective, owing to a simple molecular stmcture. TSH has been used in the veterinary treatment of hypothyroidism, and preparations of TSH ate produced by Cooper Animal Health, Inc. and Armour Pharmaceuticals. 

Figure 1 A schematic diagram of the endocrine system of fish. TRH = thyrotrophin releasing hormone GnRH = gonadotrophin releasing hormone CRH = corticotrophin releasing hormone TSH = thyroid stimulating hormone GtH = gonadotrophins I and II ...

The primary protection for high temperature, which could lower the maximum allowable working pressure below the PSV setting, is a high-temperature sensor (TSH), which shuts in the inlet or the source of heat. Back-up protection is provided by leak detection devices. 

Once the FMEA is completed, the specific system is analyzed to determine if all the devices are indeed needed. For example, if it is not possible for the process to overpressure the vessel, these devices are not required. If it is impossible to heat the vessel to a high enough level to effect its maximum working pressure, the TSH can be eliminated. 

MoTiarda Ustuiusa.—Thi-j plant is known in Xorth Aniorica an the wild hcigamot. The ft tsh herb yields from O d la f per cent, of essential oil,. inl the dried h irb, aboQt 2 7 por cent. 

Organ specific autoimmune disease Constitutively activating somatic mutation in TSH... 

PA S6 S06.003 Tsh peptidase (Escherichia coii) Potential virulence factor that cleaves human coagulation factor V... 

Thyroid autonomy appears as a solitary toxic nodule or toxic multinodular goitre. In toxic thyroid, the nodule s synthesis and secretion of thyroid hormones is autonomous from the thyroid-stimulating hormone (TSH), which is produced in the pituitary gland. Accordingly TSH is suppressed and the extranodular thyroid tissue is functionally downregulated. Thyroid autonomy occurs frequently in iodine-deficient countries, whereas it is much less common in iodine-sufficient areas. Constitu-tively activating mutations in the TSH receptor and in the Gs a protein are the major molecular aetiology of toxic thyroid nodules. 

Thyrotropin (TSH) regulates the production and secretion of thyroid hormones as well as thyroid epithelial cell growth via the TSH receptor. The TSH receptor belongs to the family of G protein-coupled receptors. It is composed of 764 amino acids. The receptor contains a long hydrophilic region orientated towards the exterior of the cell (ectodomain), 7 hydrophobic transmembrane domains and a short cytoplasmic region. 

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