Tropical pancreatitis

Tropical pancreatitis 500 mg/day x 42 days 20 Reduction in the erythrocyte MDA levels... 

In another clinical trial, researchers evaluated the effect of oral curcumin with piperine on the pain, and the markers of oxidative stress in patients with tropical pancreatitis (TP). Twenty patients with tropical pancreatitis were randomized to receive 500 mg of curcumin with 5 mg of piperine, or placebo, for 6 weeks, and the effects on the pattern of pain, and on red blood cell levels of malonyldialdehyde (MDA) and glutathione (GSH) were assessed. There was a significant reduction in the erythrocyte MDA levels following curcumin therapy compared with placebo with a significant increase in GSH levels. There was no corresponding improvement in pain. 

Normally there is very little fat in the feces. However, fat content in stools may increase because of various fat malabsorption syndromes. Such increased fat excretion is steatorrhea. Decreased fat absorption may be the result of failure to emulsify food contents because of a deficiency in bile salts, as in liver disease or bile duct obstruction (stone or tumor). Pancreatic insufficiency may result in an inadequate pancreatic lipase supply. Finally, absorption itself may be faulty because of damage to intestinal mucosal cells through allergy or infection. An example of allergy-based malabsorption is celiac disease, which is usually associated with gluten intolerance. Gluten is a wheat protein. An example of intestinal infection is tropical sprue, which is often curable with tetracycline. Various vitamin deficiencies may accompany fat malabsorption syndromes. 

In a 6-month randomised, double-blind trial to evaluate the effectiveness of two doses intramuscular vitamin D3 therapy (600,000 lU and 300,000111 weekly) in the treatment of tropical calcific pancreatitis, neither h5rpercalcaemia nor hypervitaminosis D was observed Both low- and high-dose vitamin D3 supplementations (800lU and 4370 lU daily) in multiple sclerosis patients being treated with interferon beta were not associated with any serious adverse events [46 ]. 

Reddy SV, Ramesh V, Bhatia E. Double blind randomized control study of intramuscular vitamin D3 supplementation in tropical calcific pancreatitis. Calcif Tissue Int July 2013 93(l) 48-54. 

In this model the secondary bile acid sodium deoxycholate appears to be neither tropic nor co-carcinogenic to hypoplastic defunc-tioned colon. The previously cited experiment showing that bile and pancreatic juice could stimulate adaptive mucosal hyperplasia and carcinogenesis after surgical diversion involved distal gut remaining in continuity with the faecal stream[29]. Thus any effect of bile acids in promoting colorectal neoplasia or in maintaining mucosal cell turnover is likely to depend in part on other luminal factors. 

---