Trimetaphan

Trimetaphan camsylate is incompatible with alkaline preparations, bromides, iodides, gallamine triethiodide, and thiopentone sodium. Loss of urokinase is reported when diluted with glucose solutions in PVC intravenous infusion sets.127... 

Figure 9.13. Stmcture of the ganglion-blocking agent trimetaphan.

YELLOW Amprolium, atropine methobromide, hyoscine butylbromide, hyoscine methobromide, ketoprofen, pipazethate, tetrahy-drozoline, tetramisole, trimetaphan... 

Synonyms. Methioplegium Trimetaphan Camphorsulphonate Trimethaphan Camsylate. 

Trimetaphan can double the duration of suxamethonium block (338-340). The mechanism is not clear, but may be a competitive effect at the neuromuscular junction. Blockade of end-plate ionic channels has also been suggested (341). 

Tewfik GI. Trimetaphan its effect on the pseudo-chohn-esterase level of man. Anaesthesia 1957 12(3) 326-9. 

Trimetaphan and hexamethonium can potentiate D-tubo-curarine-induced block, but clinical reports clearly showing this are lacking. Tubocurarine will increase their hypotensive effect. Neostigmine could theoretically facilitate the postulated end-plate ion channel block of trimetaphan (SEDA-13, 102) (66), which would complicate reversal of neuromuscular block. 

Mecamylamine was originally developed as a ganglion blocker and antihypertensive, but, like trimetaphan, its clinical use is now very limited, although it has been suggested as a possible therapeutic agent in Tourette s syndrome. 

Such ganglionic blocking agents that interfere with the nervous transmission of sympathetic as well as para-sympathetic ganglia may include hexa-methonium bromide mecamylamine hydrochloride pempidine pentolinium tartrate, trimetaphan camsylate, etc. 

E. Trimetaphan Camsilate INN, Trimetaphan Camsylate BAN, Trimethaphan Camsylate USAN,... 

Trimetaphan is a ganglionic-blocking agent having a very brief duration of action. Hence, it is... 

These cause hypotension, mydriasis, dry mouth, anhidrosis, constipation. urinary retention and impotence. Trimetaphan is used to produce controlled hypotension during certain surgical pnx edurcs. 

Trimetaphan can increase the effects of suxamethonium (succi-nylcholine), which may result in prolonged apnoea. This may possibly occur with other neuromuscular blocking drugs, such as alcuronium. 

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