3.4.5- Trihydroxy benzoic acid

As can be expected, the high-temperature processing runs the risk of enhancing side and consecutive reactions. Decarboxylation of the main product was found and increases with temperature (see Fig. 7). This is illustrated at the example of the synthesis of 2,4,6-trihydroxy benzoic acid from phloroglucinol, as this molecule is even more sensitive to thermal destruction due to the enhanced electron richness of the aromatic core by presence of a third hydroxyl group (Hessel et al. 2007). 

Metbylene Blue 2,2 -Methylenebis[3,4,5-trihydroxy-benzoic acid]... 

TRIHYDROXYBENZOIC ACID PROPYL GALLATE n-PROPYL-3,4,5-TRIHYDROXYBENZOATE TEXOX PG 3,4,5-TRim DROXYBENZENE-l-PROPYLCARBOXYLATE 3,4,5-TRIHYDROXY-BENZOIC ACID, n-PROPYL ESTER... 

TMBA, a drug intermediate widely used for an antibiotic Trimethoprim, has been traditionally made from gallic acid (3,4,5-trihydroxy benzoic acid) or vanillin imported from China where they extract it from a particular bark of a tree. However, during the last decade or so, it has been more economically made from p-cresol... 

Gallic Acid Gallic Acid Monohydrate 3,4, 5-Trihydroxy-Benzoic Acid ... 

Anand K K, Singh B, Saxena A K, et al. (1997). 3,4,5-trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica-hioassay guided activity. Pharmacol. Res. 36 315-321. 

Among Uk C-substituted trihydroxybenzenes the nrotonation of 2,4,6-trihydroxy-benzoic acid was studied in 70% HCIO4 and in HSO3F at —60 °C... 

Percec and coworkers [184] utilized a similar strategy for the conversion of perfluorinated alkylene functionalized 3,4,5-trihydroxy benzoic acid-type dendrons into methyl methacrylate functionalized dendritic macromonomers. Characterization of the resulting linear-dendritic architectural copolymers involved DSC, x-ray diffraction, and thermal optical polarized microscopy. It was concluded that the self-assembly of the pendant dendritic mesogens forced the linear backbone into a tilted, helical ribbon-type structure. The self-assembly behavior was largely controlled by the multiplicity, composition, and molecular weights of the pendant dendritic mesogens. 

Their chemical structure is rather complex. The main characteristic feature is that glucose (- dextrose) is partly or completely esterified with aromatic polyhydroxy carboxylic acids, e. g., gallic acid (3,4,5 trihydroxy benzoic acid) or its esters, e.g., di-galloyl-gallic acid and its condensation products. There are two classes hydrolyzable and condensed t. 

---