Triglycerides in the Liver

Mectianism of Action A combination of ethyl esters of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) that inhibits acyl coenzyme A l,2-diacylglycerol acyltransferase and increases peroxisomal oxidation in the liver. Therapeutic Effect Reduces the synthesis of triglycerides in the liver. 

Fig. 2. The relationship between levels of phospholipids and triglycerides in the livers of 36 chickens actual area under the curves given by the latrascan to the left, percentage composition to the right.

The administration of a purified diet supplemented with 1% orotic acid induces in rats a rapid accumulation of lipids in the liver [290]. Such an effect is species specific and does not seem to occur in humans. The deposition of triglycerides in the liver, accompanied by a decrease in the concentration of plasma lipids, is a common and characteristic feature of fatty liver induced by various drugs. The earliest biochemical change [291,292] detected in rats given orotic acid is an increase in the pool of uridine nucleotides paralleled by a concomitant reduction of the level of adenine nucleotides and the oxidized and reduced forms of NAD. 

There are no reliable data available regarding the exact proportion of dietary carbohydrate which is converted to triglycerides in the liver lipogenesis in adipose tissue is probably quantitatively much more important under normal circumstances (Shapiro 1957). As far as is known, no lipoprotein glyceride is liberated from adipose tissue into the plasma. 

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