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Triglyceride-lowering

Fibrates are the most effective triglyceride-lowering drugs and are used primarily in patients with elevated triglycerides and low HDL cholesterol. [Pg.190]

Fibrates are the most effective triglyceride-lowering agents and also raise HDL cholesterol levels. Combination therapy with a fibrate, particularly gemfibrozil, and a statin has been found to increase the risk for myopathy. Of the 31 rhabdomyolysis deaths reported with cerivastatin use, 12 involved concomitant gemfibrozil.25 Therefore, more frequent monitoring, thorough patient education, and consideration of factors that increase the risk as reviewed previously should be considered. [Pg.191]

Clofibrate (91) has been in clinical use for several years as a serum triglyceride lowering agent. This drug is an important hypocholesteremic... [Pg.79]

Diarylcycloalkyl derivatives, (V), prepared by the author (6) in earlier investigations were effective as lipid- and/or triglyceride-lowering chemical agents used in treating lipid metabolism disorders. [Pg.272]

As a class, cholesterol- and triglyceride-lowering drugs were the world s top category, with sales exceeding 30 billion. [Pg.20]

The development and availability of cholesterol and triglyceride-lowering agents has evolved significantly over the past 10 to 15... [Pg.1179]

Yasni, S., Imaizumi, K., Sin, K., Sugano, M., Nonaka, G., and Sidik, Identification of an active principle in essential oils and hexane-soluble fractions of Curcuma xanthorrhiza Roxb. showing triglyceride-lowering action in vais. Food Chem. Toxicol, 32 (3), 273-278, 1994. [Pg.463]

SERUM TRIGLYCERIDES LOWERING NOT CLEAR SLIGHT INCREASE... [Pg.120]

LIVER TRIGLYCERIDES LOWERING EFFECTIVE HIGHLY EFFECTIVE... [Pg.120]

Willumsen, N., Hexeberg, S, Skorve, J., Lundquist, M. Berge, R.K. (1993). J. Lipid Res. 34 13-22. Docosahexaenoic acid shows no triglyceride-lowering effects but increases the peroxisomal fatty acid oxidation in liver of rats. [Pg.204]

Fish oil, containing eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), possesses a number of henefidal effects, including the hypolipidaemic effect. It has been assumed that EPA and DHA both are hypotriglyceridaemic. However, recent animal studies have shown that EPA, but not DHA, appears to be responsible for the triglyceride lowering effect of fish oil, possibly through increased P-oxidation. Results from a recent clinical study sean to support this pathway as the primary site for the hypolipidaemic effect of n-3 fatty adds." ... [Pg.221]

The 3-thia, non-P-oxidable thia fatty acids (as exemplified by TTA (tetradecylth-ioacetic acid, HOOC-CH2-S-CH2(13)-CH3) decrease plasma triglycerides and cholesterol levels when administered to rats. At the same time TTA increased the hepatic fatty acid oxidation capacities. Recently we have demonstrated that stimulation of mitochondrial P-oxidation, but not peroxisomal fatty acid oxidation, decreases hepatic triglyceride formation. This has also been shown with co-3 fatty acids and fibrates in different animal models (rats, rabbits and dogs). Altogether the mitochondrion seems to be the principal target for the plasma triglycerid lowering effect. [Pg.311]


See other pages where Triglyceride-lowering is mentioned: [Pg.143]    [Pg.228]    [Pg.700]    [Pg.191]    [Pg.630]    [Pg.271]    [Pg.272]    [Pg.944]    [Pg.263]    [Pg.271]    [Pg.1006]    [Pg.160]    [Pg.308]    [Pg.313]    [Pg.228]    [Pg.700]    [Pg.660]    [Pg.267]    [Pg.317]    [Pg.938]    [Pg.188]    [Pg.312]    [Pg.444]    [Pg.378]    [Pg.612]    [Pg.90]    [Pg.95]    [Pg.104]    [Pg.104]    [Pg.111]    [Pg.56]    [Pg.199]    [Pg.225]   
See also in sourсe #XX -- [ Pg.56 ]




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