Trigeminal neurons

Hippocampus (pyramidal cells) olfactory bulb (granule cells, periglomerular cells) cerebral cortex amygdala hypothalamus superior colliculus superior olivary neurons spinal trigeminal neurons spinal cord... 

Akerman, S., H. Kaube, and P. J. Goadsby. Anandamide is able to inhibit trigeminal neurons using an in vivo model of trigeminovascular-medi-ated nociception. J Pharmacol Exp Ther 2004 309(1) 56-63. 

H., Mishina, M. Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor s2 subunit mutant mice, Neuron 1996, 16, 333-344. 

Pose I, Sampogna S, Chase MH, Morales FR (2003) Mesencephalic trigeminal neurons are innervated by nitric oxide synthase-containing fibers and respond to nitric oxide. Brain Res 960 81-9 Prast H, Philippu A (1992) Nitric oxide releases acetylcholine in the basal forebrain. Eur J Pharmacol 216 139 40... 

Capsaicin activates receptors in trigeminal (cranial nerve V) and intestinal neurons. These include pain receptors located in the mouth, nose, stomach, and mucous membranes. Trigeminal neurons utihze substance P as their primary pain neurotransmitter. Capsaicin first induces the release of substance P from the neuron and then blocks the synthesis and transport of substance P to the effector side (Bernstein et al, 1981 Tominack and Spyker, 1987). Substance P depolarizes nemons to produce dilation of blood vessels, stimulation of smooth muscle, and activation of sensory nerve endings (Hehne et al, 1987 Tominack and... 

Kutsuwada T, Sakimura K, Manabe T, Takayama C, Katakura N, Kushiya E, Natsume R, Watanabe M, Inoue Y, Yagi T, Aizawa S, Arakawa M, Takahashi T, Nakamura Y, Mori H, Mishina M (1996) Impairment of suckling response, trigeminal neuronal pattern formation, and hippocampal LTD in NMDA receptor e2 subunit mutant mice. Neuron 76 333-344. 

Rat mesencephalic trigeminal neurons Negro and Chandler [1997] have constructed a model of sensory neurons involved in brain stem control of jaw musculature. This model of the trigeminal neurons includes a fast sodium current, N- and T-type calcium currents, two A-type potassium currents, a sustained potassium current, a delayed rectifier potassium current, a calcium-dependent potassium current, a hyperpolarization-activated current, and a leakage current. 

Negro, C.A.D. and S.H. Chandler (1997). Physiological and theoretical analysis of K" " currents controlling discharge in neonatal rat mesencephalic trigeminal neurons. J. Neurophysiol. 77,537 553. 

The intranasal route delivery is an easy non-invasive approach to deliver biomolecules via the olfactory and trigeminal neuronal pathways to the brain, bypassing the BBB. It is considered to be the fastest and most effective way to cross the BBB to reach the CNS. Malhotra et al. developed TAT- and MGF-tagged PEGylated chitosan nanoparticles to deliver siRNA to the brain via an intranasal route. The results demonstrated maximum siRNA delivery to the brain compared with other tissues, with no cellular toxic effects. 

Yu, T., Shah, B.P., Hansen, D.R., Park-York, M. Gilbertson, T.A. Activation of oral trigeminal neurons by fatty acids is dependent upon intracellular calcium. Pflugers Arch. 2012,464 Tll-Thl. 

Rat mesencephalic trigeminal neurons, 22-13 Rat Nodose neurons, 22-12 Rattay, E, 19-15 RCPG (respiratory central... 

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