Triethylene glycol diglycidyl ether

Data were last reviewed in lARC (1976) and the compound was classified in I ARC Monographs Supplement 7 (1987). 

2 Structural and molecular formulae and relative molecular mass 

Triethylene glycol diglycidyl ether was first prepared in 1962, but has been produced commercially only on a small scale in the United Kingdom for use as an antineoplastic drug given by intravenous or intraarterial injection (lARC, 1976). 

Triethylene glycol diglycidyl ether was tested by intraperitoneal injection in a single study for lung adenoma induction in strain A mice. It increased the incidence of lung tumours at the high dose (lARC, 1976). 

Other Data Relevant to an Evaluation of Carcinogenicity and its Mechanisms 

---

The severe kidney damage seen in rats and dogs after intravenous administration of triethylene glycol diglycidyl ether has not been observed in human patients however, haematological depression (leukopenia for instance) and temporary dysuria were observed (lARC, 1976). 

Rats and dogs given intravenous doses of triethylene glycol diglycidyl ether showed necrosis of the renal tubule epithelium, of the adrenal cortex and of the intestinal epithelium. In dogs, blood neutrophils disappeared and lymphocyte counts fell to 50% of normal. Though the erythrocyte and platelet counts remained constant, the brief appearance of polychromatic and nucleated red cells indicated that erythropoiesis was also affected. 

There is inadequate evidence for the carcinogenicity of triethylene glycol diglycidyl ether in experimental animals. 

Triethylene glycol diglycidyl ether is not classifiable as to its carcinogenicity to humans (Group 3). 

C12H2206 triethylene glycol diglycidyl ether 1954-28-5 593.15 52.902 2 24885 C12H2403 2,4,6-tripropyl-S-trioxane 2396-43-2 517.15 45.534 2... 

Additives used in final products Fillers aluminum hydroxide, calcium carbonate, carbon black, graphite, mst protection fillers, zinc oxide Plasticizers biphenyl, dibutyl sebacate, diglycidyl ether of bisphenol A, dihexyl adipate, hexyl cyclohexyl adipate, polyethylene glycol, tetraethylene glycol di-n-heptanoate, triethylene glycol di-(2-ethylhexanoate) Antistatics antimony-doped tin oxide, vanadium pentoxide Antiblocking silica Release liquid paraffin, n-butyl stearate, silicone ... 

---