1.2.4- Triazole sodium salt

N-Bromosuccinimide 1,2,4-Triazole sodium salt Tetrabutylammonium bromide Iodomethane... 

Triazole sodium salt Tin(II) chloride dihydrate Formaldehyde Benzoic acid... 

Nitrobenzylbromide (21.6 g, 0.1 mol) was added to a rapidly stirred suspension of 1,2,4-triazole sodium salt (9.1 g, 0.1 mol) in anhydrous DMF (100 ml) and the mixture stirred at room temperature for 16 h. Ethyl acetate (400 ml) was added followed by water (250 ml) and the layers separated. The organic phase was washed with water (3 x 250 ml), dried (MgS04) and evaporated. The residue was chromatographed on silica gel eluting with ethyl acetate to give the title-product (10.6 g, 52%) m.p. 98°-100°C. 

Synonyms Cl 40645 Fluorescent brightener 46 4-(2H-Naphtho (1,2-d) triazol-2-yl)-2-stilbenesulfonic acid sodium salt 2-(4-(2-Phenylethenyl)-3-sulfophenyl)-2H-naphtho (1,2-d) triazole sodium salt Empirical C24H16N3O3S Na Properties M.w. 449.48 Toxicology LD50 (oral, mouse, 4 h) > 10 g/m LCLo (inh., rat, 4 h) 4500 mg/m mildly toxic by inh. primary eye and skin irritant mutagen TSCA listed... 

Dihydro-3-methoxy-4-methyl-5-oxo-A/-[[2-(tri-fluoromethoxy)phenyl]sulfonyl]-1H-1,2,4-triazole-1-carboxamide, sodium salt... 

The drug discovery route to rizatriptan (1) began with the preparation of 1-(4 -nitrobenzyl)-l,2,4-triazole 5 using 4-nitrobenzyl bromide (4) and 1,2,4-triazole. (Scheme 4.1). Benzylation of the sodium salt of 1,2,4-triazole prepared with NaH was not regioselective and afforded a 1.5 1 mixture of l-(4 -nitrobenzyl)-1,2,4-triazole (5) and its regioisomer, 4-(4 -nitrobenzyl)-l,2,4-triazole. The desired isomer 5 was isolated in 52% yield after silica gel chromatography. Hydrogenation... 

Several 9-(2, 3 -0-isopropylideneglycerolyl)-8-azahypoxanthine and 8-aza-adenines were synthesized by a 1,3-dipolar cycloaddition of racemic or (5)-l-azidoglycerolyl derivative 1084 with the sodium salt of malononitrile or cyanoacetamide to afford the intermediate triazoles 1085 and 1088, which... 

Recently a novel member of the meso-ionic class of l,2,4-triazole-3-thiones (227) has been described. Heating the sodium salt, Ph-CO-NPh-NH-CS—S-CHj—COjNa, with hydrazine gave the compound 227, R = R = Ph, R = NHj, which was characterized as a monobenzylidene derivative. The meso-ionic hydrazine derivative 227, R = R = Ph, R = NHj, undergoes an interesting reaction with nitrous acid, yielding the l,2,4-triazoline-3-thione (239). ... 

N 44.59%. Solid, explg when dry at 120—130° as well as on friction. Can be prepd by treating the sodium salt of 5-amino-l,2,4-triazole-3-carboxylic acid with NaNO, in dil aq HC1 at ca -3° (Refs 2 3)... 

The first important member of this group was 4,4 -bis(6-sulfonaphtho 1,2-disulfonic acid. As the tetrasodium salt [7426-67-7] [57], however, it produced a greenish white brightening effect on cotton. Removal of one of the naphthotriazole groups resulted in asymmetric compounds giving a neutral white, but at the cost of efficiency, e.g., the sodium salt of 4-(2H-naphtho[l,2-rf ]triazol-2-yl)stilbene-2-sulfonic acid [58],... 

Katritzky et al. have described synthetic routes toward l//-tetrazole-5-dinitromethylide sodium salt 618 <2005CHE111>. Energetic salts comprised of substituted tetrazolium cations and the 3,5-dinitro-l,2,4-triazolate anion, viz. 1,4,5-trimethyltetrazolium 3,5-dinitro-l,2,4-triazolate 619 and 4,5-dimethyl-l-aminotetrazolium 3,5-dinitro-1,2,4-triazolate 620, were obtained and characterized by Shreeve and co-workers <2005JMC3459>. 

Chemical Name 4-Thia-l-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-methyl-7-oxo-3-(lH-l,2,3-triazol-l-ylmethyl)-, 4,4-dioxide, (2S,3S,5R)-, sodium salt... 

Dipolar cycloaddition of the sodium salt of cyanoacetamide or mal-ononitrile to the acetonide of racemic or optically active l-azido-2,3-dihydroxypropane 290 afforded the intermediate triazoles 291, which were converted directly to the 2-substituted 9-(2, 3 -dihydroxypropyl-8-azahypoxanthines 294 and 8-azaadenines 295 by treating with a suitable ester or nitrile to give the isopropylidene derivatives 292 and 293, respectively, followed by acid hydrolysis. The percentage of racemization was determined by NMR with the Europium shift reagent [Eu(tfc)3] (91JHC1351) (Scheme 58). 

Dihydro-2iT-thiazolo[2,3-c][l,2,4]triazine-3,4-dione rearranges in dilute base to give an unstable acid which decarboxylates on acidification of the sodium salt to give 5,6-dihydrothiazolo[2,3-c]-s-triazole (equation 68) (81CB1200). Kinetic evidence has been put forward in favor of covalently hydrated intermediates in the acid-catalyzed rearrangement of triazolo[4,3-a]pyrazines to 1H-imidazo[2,1 -c]-s-triazoles. The intermediate triazole has been isolated and characterized (equation 69) (72JCS(P2)4). 

Methylindole, imidazole, and various triazoles were also TV-arylated. In the case of 1,2,4-triazole 83, 1,2,3-benzotriazole and indole derivatives, good yields of the Ar-aryl derivatives were only obtained upon treatment of the sodium salt of the substrate with />-tolyllead triacetate 58 in the presence of copper diacetate at 50-90 °C (Equation (85)).110... 

Similarly, the 2-azidoethylene-l,l-dicarbonitriles (92) were found to react with aniline to give the corresponding anilino derivatives 121 Reaction of phenyl ethynyl ketone with sodium azide in an aqueous medium, it will be recalled, gave the isoxazole 74 (R = H). When this reaction was carried out in dimethylformamide, quite different results were found in this case the sodium salt of 4-benzoyl-1,2,3-triazole was isolated in good yield . The formation of this product... 

Hoover and Day. In this, the triazole is stirred with liquid ammonia while small pieces of sodium are added until a faint blue color persists. This color is discharged with a little ammonium chloride, and the solvent is allowed to evaporate overnight. After the toluene formed in the reaction has been removed under vacuum, the remaining white sodium salt is dissolved in a little ice water. The highly alkaline solution is acidified with hydrochloric acid and the product filtered. In this way, these authors debenzylated the 4-amino-3-benzyl derivatives of 1,2,3-triazole (37%), and its 5-carboxamide (66%), 5-carboxyhydrazide (50%), and 5-nitrile (86% yields) (56JA5832). 

Sodium salts of 1-aroylamino-u-triazoles (124) are acylated at low temperature at the oxygen atom, affording isoimides 122. The latter compounds, as already noted, are isomerized on heating to l-(A,A-diaroyla-mino)-u-triazoles (78JHC1255 84JHC1653). 

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