177-1,2,4-Triazole-3-carboxylate

Intramolecular cycloaddition between an azide and an unsaturated ester (see 300) was the key step in the synthesis of triazole carboxylic acids 302 a, b, prospective anionic sugar mimics (Eq. 33) [79]. 

Ribavirin is reversibly phosphorylated by all nucleated cells. It is also metabolized in the liver to a triazole carboxylic acid metabolite that is eliminated in the urine along with the parent compound. The plasma half-life of ribavirin is 9.5 hours when it is administered by aerosol (2.5 hours/day for 3 days), whereas its half-life is around 12.5 days at steady state. The drug accumulates in erythrocytes, with a half-life of 40 days. 

Patent One Step Synthesis of 1,2,3-Triazole Carboxylic Acids... 

Utility Improved Method for Preparing 1,2,3-Triazole Carboxylic Acid... 

Ethyl l-hydroxy-lH-l,23-triazole -carboxylate 161 Gong, Y. D., Tanaka, H., Iwasawa, N., Narasaka, K. BCSJ71, 2181 (1998). 

The positive charge on nitrogen atom two will cause the triazole ring to act as a strong electron-attracting group. This idea has been confirmed by measurements of the dissociation constants of the triazole carboxylic acids, which have shown (see Table IV, p. 121) that acids... 

Virazole. Guanosine was used as a ribose donor. Triazole carboxyl amide (TCA), which is an artificial base, was the ribose acceptor for Virazole synthesis. The screening of microorganism at GO G showed Brevibacterium acetylicum to be the best strain for Virazole preparation. 

Amino-l,2,4-triazole has been prepared by evaporating formylguanidine nitrate with sodium carbonate, and from 5(3)-amino-1,2,4-triazole carboxylic acid-3(S) by heating above its melting point, or by a long digestion with acetic acid. ... 

Safarifard V, Morsali A. Mechanochemi-cal solid-state transformations from a 3D lead(II) chloride triazole carboxylate coordination polymer to its bromide/thiocyanate analogs via anion-replacements precursors for the preparation of lead(II) chlo-ride/bromide/sulfide nanoparticles. Cryst Eng Commun 2012 14(16) 5130. 

Safarifard V, Morsali A. Solid state syntheses of nano lead(II) iodide triazole carboxylate coordination polymer from its bromide/ thiocyanate/chloride analogs via mechanoche-mical crystal to crystal transformations. Inorg Chim Acta 2013 405 203- . 

The substituted amido-triazole carboxylates can be used as stereodefined scaffolds for the preparation of triazole-containing peptidomimetics or as generic scaffolds for the preparation of diverse trisubstituted amino triazoles. 

In peptide syntheses, where partial racemization of the chiral a-carbon centers is a serious problem, the application of 1-hydroxy-1 H-benzotriazole ( HBT") and DCC has been very successful in increasing yields and decreasing racemization (W. Kdnig, 1970 G.C. Windridge, 1971 H.R. Bosshard, 1973), l-(Acyloxy)-lif-benzotriazoles or l-acyl-17f-benzo-triazole 3-oxides are formed as reactive intermediates. If carboxylic or phosphoric esters are to be formed from the acids and alcohols using DCC, 4-(pyrrolidin-l -yl)pyridine ( PPY A. Hassner, 1978 K.M. Patel, 1979) and HBT are efficient catalysts even with tert-alkyl, choles-teryl, aryl, and other unreactive alcohols as well as with highly bulky or labile acids. 

Triazole-l-carboxylic acid, 4-aryloxy-, ethyl ester... 

Triazole-4-carboxylic acid, 5-chloro-1-phenyl-UV, 5, 685 (55JA6532)... 

Pyrazolo[3,2-c][l,2,4]triazole-7-carboxylic acid synthesis, 6, 1018 Pyrazolotriazoles dye releasers... 

Triazole-4-carboxylic acid, 2-phenyl-cleavage reactions, 5, 697... 

Triazole has been prepared by the oxidation of substituted 1,2,4-triazoles, by the treatment of urazole with phosphorus pentasulfide, by heating equimolar quantities of formyl-hydrazine and formamide, by removal of the amino function of 4-amino-l,2,4-triazole, by oxidation of l,2,4-triazole-3(5)-thiol with hydrogen peroxide, by decarboxylation of 1,2,4-triazole-3(5)-carboxylic acid, by heating hydrazine salts with form-amide,by rapidly distilling hydrazine hydrate mixed with two molar equivalents of formamide, i by heating N,N -diformyl-hydrazine with excess ammonia in an autoclave at 200° for 24 hours, and by the reaction of 1,3,5-triazine and hydrazine monohydrochloride. ... 

Phenylmethyltriazole Carboxylic Acid. —The mother substance of this compound is a triazole, viz., pyrro-n/ d-diazolc, which is one of four isomeric compounds ... 

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