Triacylglycerol and Energy Storage

FA stored within the TAG of adipose ceUs constitute the vast majority of energy reserves in animals. While the TAG pool in adipocytes provides a reservoir of energy for times of prolonged restricted caloric intake, there is also a normal acute flux of FA into and out of adipose tissue in response to meals and other factors, such as insuhn [8, 9J. TAG hydrolysis in adipocytes, termed hpolysis, contributes to the increased levels of plasma NEFA by two mechanisms, one direct and the other indirect. In the post-absorptive state or during starvation FA are normally released from adipocytes directly into the plasma and transported to various tissues where they serve as a source of energy. In the insulin-resistant state this direct release of FA is exacerbated, because the reduction in the anti-lipolytic action of insuhn (see below) leads to increased hpolysis and a consequent increase in the release of FA from adipocytes into plasma. In contrast to the postabsorptive direct FA release, there is 

Epidermal growth factor Antagonism of lipolytic catecholamine effect 

Gastric inhibitory peptide Stimulation of TAG storage and amplification 

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