TrEMBL

There is a tremendous increase in sequence data owing to technological advances (such as sequencing machines), the use of new biochemical 

A typical TrEMBL entry is shown in Fig. 2. A TrEMBL entry looks much like a SWISS-PROT entry, because TrEMBL follows the SWISS-PROT format and conventions as closely as possible. A few differences affect the ID and DT lines. 

As explained previously, the very first line of a SWISS-PROT entry is the ID line— ID for identification—and is made offour different parts  

A TrEMBL ID line is also made of four parts  

The SWISS-PROT and TrEMBL ID lines differ in the first two parts of the ID line. The first part is the entry name ANP NOTCO in the case of the SWISS-PROT example and Q12757 in the TrEMBL example. The entry name used in all SP-TrEMBL entries is always the same as the accession number of the entry. The entry name used in REM-TrEMBL is the Protein ID tagged to the corresponding CDS in the EMBL Nucleotide Sequence Database. To the right of the entry name you will find either preliminary (in the TrEMBL entry) or STANDARD (in the SWISS-PROT entry). The data class used in TrEMBL is always PRELIMINARY. That means that the data are thoroughly checked by a computer, 

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Swiss-Prot, TrEMBL Annotated non-redundant protein sequence database, TrEMBL is a computer-annotated supplement to Swiss-Prot. TrEMBL contains the translations of all coding sequences present in the EMBL Nucleotide Sequence Database which are no yet integrated into Swiss-Prot... 

TrEMBL http / / www.expasy.ch/sprst/sprst-top.html... 

A Bairoch, R Apweiler. The SWISS-PROT protein sequence data bank and its supplement TrEMBL m 1999. Nucleic Acids Res 27 49-54, 1999. 

Erbauung, /. building, foundation edification. Erbe, m. heir. — n. inheritance, erbeben, v.i. shake, tremble. 

Schiittergebiet, n. (Geol.) region cd disturbance, schuttern, v.i. shake, tremble, vibrate. — v.t. shake. 

Biological raw data are stored in public databanks (such as Genbank or EMBL for primary DNA sequences). The data can be submitted and accessed via the World Wide Web. Protein sequence databanks like trEMBL provide the most likely translation of all coding sequences in the EMBL databank. Sequence data are prominent, but also other data are stored, e.g.yeast two-hybrid screens, expression arrays, systematic gene-knock-out experiments, and metabolic pathways. 

Bairoch A, Apweiler R (2000) The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res 28 45-48... 

Lichtman et al. 2001 Tzavaraet al. 2000). A dog model of precipitated cannabinoid withdrawal, which includes increased salivation, vomiting, diarrhea, restless behavior, and trembling, has also been described (Lichtman et al. 1998). 

Evidence of neurotoxicity was also observed in animal studies. Nose-only exposure of rats to endosulfan at concentrations of 3.6 mg/m in females and 12.3 mg/m in males resulted in trembling and ataxia (Hoechst 1983a). At higher concentrations in both sexes, tremors, tonic-clonic convulsions, and reduced corneal, pupillary, placing, shock, paw-pinch, and cutaneous reflexes were observed. Nose-only exposure of male and female rats to concentrations of endosulfan of up to 2 mg/m for 6 hours/day,... 

I knew where she meant in me, for a faint, fearful excitement trembled there when I thought of such matters and made me run my hands secretly over my breasts and waist and thighs. Does... How does he ... 

My fears for Antony never wholly left me, any more than my fear for John had the King s silent grief touched it and made my voice tremble just a little. Such a sorrow is hard to bear. And perhaps the more for those not granted time to mourn. ... 

He laughed and the shock of the sound made my rigid grip tremble. Then obey your father and your king in this, sweet Ysa—see I know your true name. Be a dutiful daughter and subject and come to me, and we shall have such pleasure as no man and woman ever had, this day and for many a long day and night to come. ... 

May I copy this I say to Anne Stewart, as I pull notebook and pencil out of my bag. My hands are trembling and I drop both on the floor. 

She was trembling. "I haven t been able to get a translator," she said. "I can read a little. But Charmatz is better at German than I."... 

The letter trembled on Szpilfogel s lap in his hands was Von Schnitzler s letter to Schwab ... 

Taiep rat (acronym trembling, ataxia, immobility, epilepsy, paralysis) AR Unknown Impaired myelin formation followed by demyelination in the CNS accumulation of microtubules in oligodendrocytes interferes with transport of myelin proteins or mRNAs see text 49... 

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