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Treatment neural stem cell transplants

Other treatments remain both experimental and controversial, including stem cell transplants, implantation of fetal nerve cells, and the infrocudtion of genetically engineered cells into neural tissue. [Pg.762]

Several ceU sources have been used for experimental ceU therapy approaches pluripotent stem cells like embryonic stem cells from the blastocyst and embryonic germ cells [47, 48], human cord-blood derived cells [49], but also cultured cell lines. Neural stem cells (stem cells forming neuronal as well as glial cell lineages) isolated from different parts of the brain known to harbor multipotent neural stem cells [50-52] are also an option. In a non-neurode-generative indication, a cultured cell line was used to treat patients after stroke in a pilot clinical trial. The cells were transplanted in the paramedian plane and treatment was reported to be safe, with signs of efficacy [53]. [Pg.342]

With the confirmation that neurogenesis occurs in the adult brain, and the recent isolation and characterization in vitro of neural progenitor and stem cells from the adult CNS, new avenues for the treatment of neurological diseases and injuries are being considered. Cell therapeutic interventions may involve both in vivo stimulation and transplantation of neural progenitor and stem cells. [Pg.22]

Today, with the exception of bone marrow for hematopoietic reconstitution, therapeutic cellular transplantation is an emerging technology. In recent years novel approaches in the potential restoration of function through cellular transplantation have included the use of fetal human or xenogeneic neural tissue for Parkinson s disease, ectopically implanted pancreatic islets for diabetes, Schwann cells and olfactory ensheathing glia for spinal cord injury, encapsulated chromaffin cells for pain, and various types of stem cells for the treatment of diabetes, cardiac disease, and central nervous system injuries or disease [2], There have also been trials of encapsulated cells to provide enzymes that either remove toxic products or provide activation of prodrugs to therapeutics, usually anticancer derivatives. [Pg.750]


See other pages where Treatment neural stem cell transplants is mentioned: [Pg.513]    [Pg.19]    [Pg.93]    [Pg.144]    [Pg.53]    [Pg.151]    [Pg.151]    [Pg.1]    [Pg.7]    [Pg.25]    [Pg.37]    [Pg.37]    [Pg.50]    [Pg.51]    [Pg.56]    [Pg.98]    [Pg.145]    [Pg.89]    [Pg.171]    [Pg.172]    [Pg.357]    [Pg.534]    [Pg.665]   
See also in sourсe #XX -- [ Pg.162 ]

See also in sourсe #XX -- [ Pg.162 ]




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Cell transplantation

Treatment stem cell transplants

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