Transmetalation Reactions Producing Organocopper Reagents

In this chapter, we will emphasize these recent developments, especially those that allow the preparation of organocopper species not accessible through the standard procedures involving organolithiums as precursors and their use in reactions with organic electrophiles. 

Many functional groups are incompatible with organolithium reagents. Execution of transmetalations at very low temperatures, however, enables functionalized 

CuCN-2LiCl. This can then be selectively allylated vith allyl bromide to provide the dibromoimidazole 36, which can now be magnesiated by treatment with a further equivalent of iPrMgBr, providing the ester-substituted imidazole 37 in 55% yield after carboxylation with ethyl cyanoformate [25]. 

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Knochel, P. Betzemeier, B. Transmetalation Reactions Producing Organocopper Reagents. In Modem Organocopper Chemistry Krause, N.,... 

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