General Mechanisms of Cellular, Cap-Dependent Translation Initiation

General Mechanisms of Cellular, Cap-Dependent Translation Initiation 

Translation initiation of a eukaryotic, cellular mRNA is a complicated process requiring various protein factors to assemble the ribosome at the proper start site (Fig. 2). There are several different models of ribosomal recruitment to the mRNA. The model presented below explains translation of most cellular mRNAs [for alternative mechanistic 

The structure of an unrelated cap-binding protein (VP39) has been determined in its apo form and in the presence of various cap analogues 

FRAP/mTOR phosphorylates 4E-BP1 both in vivo and in vitro, and expression of a rapamycin-resistant form of FRAP/mTOR inhibits 4E-BP1 phosphorylation. 4E-BP1 appears to be phosphorylated at 

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III. General Mechanisms of Cellular, Cap-Dependent Translation Initiation. 274... 

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