Transition State Theory Free-Energy Diagrams

7 Transition State Theory Free-Energy Diagrams 

The reaction between chloromethane and hydroxide ion in aqueous solution is highly exergonic at 60°C (333 K), AG° = 100 kJ mol (The reaction is also exothermic, 

The equilibrium constant for the reaction is extremely large, as we show by the following calculation  

An equilibrium constant as large as this means that the reaction goes to completion. 

Most chemical reactions occur much more rapidly at higher temperatures. The increase in reaction rate for Sn2 reactions relates to the fact that at higher temperatures the number of collisions between reactants with sufficient energy to surmount the activation energy (AG ) increases significantly (see Fig. 6.3). 

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TRANSITION STATE THEORY FREE-ENERGY DIAGRAMS... 

Free energy diagrams for enzymes REACTION COORDINATE DIAGRAM ENZYME ENERGETICS POTENTIAL-ENERGY SURFACES TRANSITION-STATE THEORY ARRHENIUS EQUATION VAN T HOFF RELATIONSHIP... 

There is one further important aspect of this system that relates to the species whose free energies control the product ratio. This aspect can be developed in terms of transition-state theory and the reaction coordinate diagram in Figure 2.1. 

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