Transgenic mice gene regulation

Robertson GR, Field J, Goodwin B, Bierach S, Tran M, Lehnert A, Liddle C. Transgenic mouse models of human CYP3A4 gene regulation. Mol Pharmacol 2003 64 42-50. 

Although gene deletion models have been useful to confirm that HIF-la is a critical regulator of breast eaneer growth and metastasis, these animal models do not mimic what is actually observed in the clinic, which is over-expression of HIF-la. Generation of novel transgenic mouse models in which HIF-la is... 

Beermann, F., Schmid, E., and Schtitz, G. (1992a). Expression of the mouse tyrosinase gene during embryonic development recapitulation of the temporal regulation in transgenic mice. Proc. Natl. Acad. Sci. USA 89 2809-2813. 

Transgenic humanized mouse (human receptor) Allows testing of the clinical product May overestimate response Difficult to extrapolate a positive response May not have appropriate physiological regulation of gene expression May not have appropriate physiological response to test article... 

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