Genomics transcriptomics

Integrated Functional Genomics Transcriptomics, Proteomics, and Metabolomics... 

The information gleaned from analysis of the genome, transcriptome and proteome can be integrated to prioritize proteins for intensive investigation. Each will need to be expressed as a recombinant or formulated as a DNA construct for rigorous testing of its protective... 

Augen, J., 2005, Bioinformatics in the post-genomic era Genome, transcriptome, proteome, and information-based medicine, Addison-Wesley (388 pages, paperback). 

Martmez D, Challacombe J, Morgenstem I et al (2009) Genome, transcriptome, and secre-tome analysis of wood decay fungus Postia placenta supports unique mechanisms of ligno-cellulose conversion. Proc Natl Acad Sci USA 106 1954-1959... 

Case Study 1 Combined Genome, Transcriptome and Proteome Analysis on a Parent Strain and an L-Threonine-Overproducing Mutant Strain... 

In the whole biosphere, it is estimated that there are about 100000 compounds with a molecular weight lower than about 1000 Da produced in living species. In a human, the metabolome is estimated to be no higher than about 3000 compounds. In comparison, the number of genes is 25 000 to 30 000, the number of transcripts is 100 000 to 200 000 and it is estimated that there are up to 1000 000 different proteins, including post-translational modifications. Because the metabolome is composed of a limited number of compounds, metabolomics provides data that are less complex and more quantitative than genomics, transcriptomics and proteomics. 

Despite the enormous efforts in the biotechnological production of plant secondary metabolites, only three commercial processes have so far been implemented and no genetically modified plant is currently cultivated for the production of secondary metabolites. On the other hand, continuous and rapid advances in plant genomics, transcriptomics and proteomics could make the production of plant natural products by cell culture, transgenic plants or transfected microbial cells much more relevant in the future. 

P.A., Innovative cancer dmg targets genomics, transcriptomics, and clinomics, Expert Opin. Pharmacother. 2, 911-915, 2001. 

Psychogenomics The process of applying the tools of genomics, transcriptomics, and pro-teomics to understand the molecular basis of behavioral abnormalities. 

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