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Transcriptional dysregulation

DNA arrays are also useful in the studies of transcriptional dysregulation for many diseases so as to discover how different genes express themselves under certain pathological and pharmacological conditions. [Pg.334]

Other potential approaches involve the use of anti-apoptotic treatments, such as caspase-1 inhibitors or HDAC inhibitors which may interfere with the transcriptional dysregulation seen in Huntington disease. Both approaches have resulted in encouraging results in animal experiments. The use of growth factors has also been suggested as possible treatment for Huntington s disease. [Pg.773]

BitheU A, Johnson R, Buckley NJ (2009) Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington s disease. Biochem Soc Trans 37 1270-1275... [Pg.349]

Luthi-Carter R, Cha J-HOJ (2003) Mechanisms of transcriptional dysregulation in Huntington s disease. Clin Neurosci Res 3 265-177. [Pg.400]

What underlies transcriptional dysregulation In the case of PD, mutations in transcriptional factors themselves are an emerging theme. Two recent genetic association studies in a screening sample of large cohorts of individuals with idiopathic PD have revealed evidence for a novel association of PITX3 promoter... [Pg.22]

Nevertheless, HDAC inhibition is a propitious avenue to pursue the clinical treatment of neurodegenerative disorders it is already apparent that their realm of influence in treating neurodegenerative disorders is far more reaching than the original conception of reversing transcriptional dysregulation. [Pg.42]

Yacoubian TA et al (2008) Transcriptional dysregulation in a transgenic model of Parkinson disease. Neurobiol Dis 29(3) 515-528... [Pg.48]

Robakis NK (2003) An Alzheimer s disease hypothesis based on transcriptional dysregulation. Amyloid 10(2) 80-85... [Pg.48]

Desplats PA, Lambert JR, Thomas EA (2008) Functional roles for the striatal-enriched transcription factor, Bell lb, in the control of striatal gene expression and transcriptional dysregulation in Huntington s disease. Neurobiol Dis 31 298-308... [Pg.311]

See other pages where Transcriptional dysregulation is mentioned: [Pg.772]    [Pg.280]    [Pg.5]    [Pg.9]    [Pg.177]    [Pg.267]    [Pg.287]    [Pg.395]    [Pg.578]    [Pg.395]    [Pg.578]    [Pg.22]    [Pg.23]    [Pg.23]    [Pg.25]    [Pg.210]    [Pg.290]   
See also in sourсe #XX -- [ Pg.22 , Pg.25 ]



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Control and Dysregulation of Gene Transcription in Neurodegeneration

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