Transcription factors development

Millane RC, Kanska J, Dufiy DJ, Seoighe C, Cunningham S, Plickert G, Prank U. Induced stem cell neoplasia in a cnidaria by ectopic expression of a POU domain transcription factor. Development. 2011 138 2429-39. 

Baumann, K. et al. (2007) Control of cell and petal morphogenesis by R2R3 MYB transcription factors. Development 134, 1691-1701... 

Originally described in the immune system, NFAT proteins comprise a family of transcriptional factors that play key roles in many cellular processes that control not only immune responses but also the development, regulation, and differentiation of many other tissues. Activation of NFAT proteins results in the expression of specific sets of genes that regulate multiple cell functions [1,2]. 

NFAT was first described in cells of the immune system, but these transcription factors are widely expressed and their function is crucial in the regulation, development, and differentiation of many nonimmune tissues. 

NFAT2 plays a key role in the development of the embryo s heart. In the precursor cells, there is a temporal and spatial specific expression of NFAT2, which directs the formation of the valves and the septum in the heart. In the adult heart, NFAT proteins also cooperate with transcription factors of the GATA and MEF2 families to regulate cardiac muscle hypertrophic responses. 

In addition to those described above, some of the newest compounds emerging in SERM development are ER 3-selective ligands and pathway-selective modulators that target the interaction of the ERs with the transcription factor NFkB. While such compounds are in the early stages of clinical evaluation, thus far they demonstrate great potential for use in the treatment of inflammatory disorders such as arthritis, inflammatory bowel disease, and like other SERMs, cancer [4]. 

While much has been learned about the HS response, our understanding is still incomplete. Why, for instance, are there multiple HS transcription factors Are some of these factors utilized during development and cellular differentiation ... 

TRANSCRIPTION FACTORS IN MAMMALIAN DEVELOPMENT MURINE HOMEOBOX GENES... 

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