Tracking Origin of Sulfur Atom in Saccharin Synthesis

4 Tracking Origin of Sulfur Atom in Saccharin Synthesis [Pg.109]

In the Maumee Chemical [60] plan for saccharin, there is a curiosity with respect to the oxidation number of the sulfur atom in the source material as shown in step 1 of the following scheme. It conld be either sodium sulfide (oxidation number = -2) or elemental sulfur (oxidation number = 0). In this case, the arithmetic mean of these valnes was nsed as the oxidation number of the sulfur atom in the starting material (oxidation number = -1) which, by the way, corresponds to the oxidation number of sulfur in disodium disulfide that is generated in situ from sodium sulfide and elemental sulfur. [Pg.109]

Sequence of steps to determine global material efficiency green metrics and synthesis efficiency parameters for any synthesis plan [Pg.109]

Obtain detailed experimental procedures for all reactions in the synthesis plan from literature references. [Pg.109]

Write out set of complete balanced chanical equations for each reaction in the plan showing stmetnres, stoichiometric coefficients, and MWs of all reagents, target product, and byproducts. Note which intermediates are isolated and assign individual reaction yield performances accordingly. Note reaction steps that are telescoped, that is, those that involve sequential ch ical transformations without isolation of intermediate products. Note the number of branches involved in the synthesis plan. [Pg.109]

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