Maumee Chemical

It is not recommended to prep large batches because of the possibility of accidental expln during vacuum distn of benzotriazole. One such expln took place in 1956 at the Maumee Chemical Plant, Toledo, Ohio(Ref 8)... 

A number of methods are available for the synthesis of saccharin. For many years, the most popular process was one developed by the Maumee Chemical Company of Toledo, Ohio, in 1950. This method begins with anthranilic acid (oaminobenzoic acid C6H4(NH2)C00H), which is treated successively with nitrous acid (HN02), sulfur dioxide (S02), chlorine (Cl2), and ammonia (NH3) to obtain saccharin. Another process discovered in 1968 starts with o-toluene, which is then treated with sulfur dioxide and ammonia to obtain saccharin. 

C. Fahlberg-I. Remsen (1879), C. Fahlberg G1 (1884-1909), C. Fahlberg G2 (1895), A. Vogel (1948), Maumee Chemical Co. (1954), Maumee-Sherwin-Williams (1980s), Rhone-Poulenc (1973), BASF (1984) W.L. Faith (1966)... 

In the Maumee Chemical [60] plan for saccharin, there is a curiosity with respect to the oxidation number of the sulfur atom in the source material as shown in step 1 of the following scheme. It conld be either sodium sulfide (oxidation number = -2) or elemental sulfur (oxidation number = 0). In this case, the arithmetic mean of these valnes was nsed as the oxidation number of the sulfur atom in the starting material (oxidation number = -1) which, by the way, corresponds to the oxidation number of sulfur in disodium disulfide that is generated in situ from sodium sulfide and elemental sulfur. 

K. E. Eoley, Chemical Properties and Uses of the yinderson s Com Cob Products, Anderson s brochure, Maumee, Ohio, 1978. 

M Industrial Chemical Products Div., St. Paul MN 55144-1000 DIBF, 5,7-diiodo-3-butoxy-6-fluorone (H-Nu 470), Spectra Group, Ltd., Maumee, OH 43537 OPPI, 4-octyloxyphenyl-phenyliodonium hexafluoroantimonate, G. E. Silicones, Waterford, NY 12188 and DIDMA, N,N-dimethyl-2,6-... 

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