Toxicity susceptibility

Calabrese EJ. Toxic Susceptibility Male/Female Differences. New York John Wiley, 1985. 

Pesce AJ, McKean DL. Toxic susceptibilities in the newborn with special consideration of polysorbate toxicity. Ann Clin Lab Sci 1989 19(l) 70-3. 

Catalyst deactivation is often characterized through empirical parameters. Some authors (refs, 5-8) have used parameters like tolerance, toxicity, susceptibility or initial deactivation which are directly obtained from the experimental deactivation curves. In other cases (refs. 9-11), experimentally found deactivation equations have been employed as an approximation of the actual deactivation law (linear, hyperbolic, exponential or power equations). While the use of such a kind of parameters provide useful information on the catalyst sensitivity to a given poison, the approach of obtaining the deactiv-... 

CALABRESE, E.J. (1985) Toxic Susceptibility Male/Female Differences (New York John Wiley). CALDWELL, J. (1981) The current status of attempts to predict species differences in drug metabolism. DrugMetab. Rev., 12, 221. 

Catalyst deactivation is often characterized through empirical parameters. Some authors (refs. 5-8) have used parameters like tolerance, toxicity, susceptibility or initial deactivation which are directly obtained from the... 

Experiments involving the use of dimethyl sulphate should be carried out by students only under immediate supervision. Not only is the vapour of dimethyl sulphate highly poisonousy but the cold liquid itself is absorbed easily through the skin, with toxic results individual susceptibility to ditnethyl sulphate poisoning varies and may be very high. If the sulphate is splashed on to the hands, wash immediately with plenty of concentrated ammonia solution in order to hydrolyse the methyl sulphate before it can be absorbed through the skin (see p. 528). 

Personnel Selection and Training. The quaHty of operating personnel is of paramount importance to the safe operation of a chemical plant. Operators must be intelligent and emotionally stable. Excessive use of alcohol and dmgs affects reHabiHty and can thereby render workers more susceptible to certain types of toxic exposure. Thorough medical screening is essential to avoid damaging exposures to susceptible individuals, eg, people with respiratory ailments should not be employed in areas where corrosive atmospheres could occur. 

Most of them are generally classified as poisons. Exceptions to this rule are known. A notable one is 4-dimethyl aminopyridine (DMAP) (24), which is widely used in industry as a superior acylation catalyst (27). Quaternary salts of pyridines are usually toxic, and in particular paraquat (20) exposure can have fatal consequences. Some chloropyridines, especially polychlorinated ones, should be handled with extra care because of their potential mutagenic effects. Vinylpyridines are corrosive to the skin, and can act as a sensitizer for some susceptible individuals. Niacin (27), niacinamide (26), and some pyridinecarbaldehydes can cause skin flushing. 

Eor practical purposes, the sapwood of all species may be considered to be susceptible to biodeterioration. The heartwood of some species, however, contains toxic extractives that protect it against biological attack. Among the native species that have decay-resistant or highly decay-resistant heartwood are bald cypress, redwood, cedars, white oak, black locust, and black walnut (60). Douglas-fir, several of the pines, the larches, and honey locust... 

The toxicity of a few boric acid esters has been summarized (30). In general the toxicities are directiy related to the toxicity of the alcohol or phenol produced on hydrolysis. Methyl borate has an oral rat LD q of 6.14 mL/kg in a range finding test (31) and the percutaneous LD q for the rabbit of 1.98 mL/kg. In eadier work (32), the oral LD q for the rat was 2.82 mL/kg the intraperitoneal LD q was 3.2 mL/kg. It has been shown that the mouse is more susceptible to these compounds than the rat. Methyl borate was found to be moderately irritating in an ocular toxicity test using rabbits (31,32) but only mildly irritating to skin (31). 

Some authorities question whether dmnkeimess can result from the inhalation of ethyl alcohol vapors. Experience has demonstrated that in any event such intoxication is indeed rare (281). There is no concrete evidence that the inhalation of ethyl alcohol vapor will cause cirrhosis. Liver function is definitely impaired during alcohol intoxication (282), making the subject more susceptible to the toxic effects of chlorinated hydrocarbons. 

IDLH means immediately dangerous to life and health. This is a concentration at which immediate action is required. The exac4 effect on an individual depends on the individuals physical condition and susceptibility to the toxic agent involved. It is the maximum airborne contamination concentration from which one could escape within 30 min without any escape-impairing symptoms or irreversible health effects (developed by NIOSH). 

Animals which are fed extensively can encounter a vast array of compounds of varying medicinal and toxic potency and susceptibilities to degradation or detoxihcation a number of texts can be consiilted. ... 

Relatively high levels of copper in pig diets can improve nutritional performance due to the antimicrobial effects in the gastrointestinal tract. However, if land is fertilized with dung from pigs and subsequently grazed by sheep, the sheep may suffer copper toxicity because of their increased susceptibility to copper compared with pigs. Similarly, pig diets would be unacceptable for sheep because of the high levels of copper therein. 

Arsenic exists as grey, yellow and black forms of differing physical properties and susceptibilities towards atmospheric oxygen. The general chemistry is similar to that of phosphorus but whereas phosphorus is non-metallic, the common form of arsenic is metallic. Traces of arsenides may be present in metallic residues and drosses these may yield highly toxic arsine, ASH3, with water. 

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