Toxicity registration, Canada

There are no listed requirements for submission of toxicity data to support registration in Canada. However, the Acts place the onus on petitioners to submit data to support the safety of their pest control products. Thus considerable latitude exists with respect to the toxicology data base which may be required for any particular compound. 

The absence of specific guidelines, or legal requirements for toxicity data submission on specified studies places the Health Protection Branch in the position that it can require any type of study prior to establishing maximum residue limits, or recommending registration to Agriculture Canada. This provides the advantage that each compound can be considered individually, and the data requirements can be tailored to fit the compound. 

No Observed Effect Level (NOEL) from Toxicity Data. The types of toxicity studies that are submitted In support of registration are similar throughout the world. In Canada there are no specific protocols delineated for the conduct of toxicity tests but most comply with those set under FIFRA, WHO. or OECD guidelines. The data requirements Include the tests outlined on Tables V, VI, and VII. These are guidelines, not rigid requirements, and the manufacturers are encouraged to discuss their data packages before completion. 

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