Toxicity bioconcentration

EPA. 1981a. Acephate, aldicarb, carbophenothion, DBF, EPN, ethoprop, methyl parathion, and phorate Their acute and chronic toxicity, bioconcentration potential and persistence as related to marine environments. Gulf Breeze, FL U.S. Environmental Protection Agency, Environmental Research Laboratory. EPA-600/4-81/04L NTIS PB81-244477. 1-275. 

Schimmel SC, Gamas RE, Patrick JM, et al. 1983. Acute toxicity, bioconcentration and persistence of AC 222,705, benthiocarb, chlorpyrifos, fenvalerate, methyl parathion and permethrin in the estuarine environment. J Agric Food Chem 31 104-113. 

Toxicity It is carcinogenic, hepatotoxic, nephrotoxic, and mutagenic to mammals Chronic toxicity may be predominant for DEHP no obvious acute toxicity Bioconcentration factor (BCF) is high, and the persistence is medium... 

Call, D.J., L.T. Brooke, R.S. Kent, M.L. Knuth, C. Anderson and C. Moriarity. Toxicity, bioconcentration and metabolism of the herbicide propanil in freshwater fish. Arch. Environ. Contam. Toxicol. 12 175-182,... 

Relationships have been found between the adsorption properties described above of surfactants and their environmental effects (toxicity, bioconcentration) on aquatic organisms (algae, fish, rotifers). The log of the EC 50 (the surfactant molar concentration in the water at which the organism population is reduced by 50% relative to a no-dose control) and the log of the BCF (the ratio of surfactant concentration in the fish relative to that in the water) have both been shown (Rosen, 1999, 2001c) to be linearly related to the parameter AG°d/u for a series of anionic, cationic, and nonionic surfactants. The values of asm and AG°d were obtained by the methods described above in Sections IIIB and IIIF, respectively. 

Schimmel, S.C., R.L. Gamas, J.M. Patrick, Jr, and J.C. Moore. Acute Toxicity, Bioconcentration, and Persistence of AC 222,705, Benthiocarb, Chlorpyrifos, Fenvalerate, Methyl Parathion, and Permethrin in the Estuarine Environment, J. Agric. Food Chem., 31(1) 104-113 (1983). 

This chapter discusses quantitative structure-activity relationships (QSARs) for predicting cation toxicity, bioconcentration, biosorption, and binding strength. Several approaches were used to identify these QSARs. First, the test systems, test substances, QSARs, and statistical analyses of each QSAR were extracted from the references cited by Walker et al. (2003). These efforts produced 21 references associated with 97 QSARs for predicting cation toxicities (Table 5.1). These QSARs are discussed in more detail in chapter Sections 5.2,5.3, and 5.5. 

QSARs for Predicting Cation Toxicity, Bioconcentration, Biosorption... 

FIGURE 1 Relationship between toxicity, bioconcentration (log Kg) and octanol/water partition coefficient (log Kq ) for some narcotic organic chemicals. 

McCarty et al. (1985) discussed combining the known relationships between acute and chronic toxicity QSARs and Kqw as well as between Kg and Kq, . The general character of the relationship between toxicity, bioconcentration, and octanol/water partition coefficient is readily apparent upon inspection of FIGURE 1, which presents equations 5, 9 and 11 for narcotic organic chemicals and fathead minnows. The relationship between acute and chronic toxicity QSARs is also clearly illustrated. 

It appears that the toxicity-bioconcentration relationship and QSKRs may provide a method for general toxico-kinetic investigations of aquatic toxicology information and may also be a means of generating kinetic parameters for both prospective and retrospective modelling. 

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