Porphyrins total

Vrij-Standhardt WG, Strik JJ, Ottevanger CF. 1979. Urinary D-glucaric acid and urinary total porphyrin excretion in workers exposed to endrin. In Strik JJ, Koeman JH, eds. Chemical porphyria in man. Amsterdam Elsevier/North Holland Biomedical Press, 113-121. 

Total porphyrin 20-320 mnol/L <35nmol/mmol creatinine ... 

In PCT, excretion and plasma porphyrin concentrations return to normal during remissionj with the proportions of individual porphyrins in urine and feces remaining abnormal for longer than total porphyrin concentrations. Thus in a patient whose skin lesions have healed, and whose total urinary and fecal porphyrin concentrations are normal, determination of individual porphyrins may reveal the diagnosis. The plasma fluorescence scan in VP and fecal coproporphyrin-III excretion in HCP remain abnormal for many years after clinical remission. 

Increased concentrations require further investigation to identify individual porphyrins porphyria should not be diagnosed on the basis of increased total porphyrin alone. 

Semiquantitative Method for Total Porphyrin in Feces This simple method for total fecal porphyrins uses scanning spectrometry after extraction and is described fully on the Evolve site that accompanies this book. 

Reference intervals are given in Table 32-3. Total erythrocyte porphyrin concentrations are increased in EPP, CEP, the rare homozygous variants of the autosomal dominant porphyrias, iron deficiency, hemolytic anemia, some other forms of anemia, and lead poisoning. A normal total porphyrin concentration excludes the diagnosis of EPP. Distinction between EPP and other causes of increased erythrocyte total porphyrin concentration requires differentiation between protoporphyrin and its zinc chelate because the acidic condition of this assay dissociates the zinc chelate and provides only a measure of total porphyrin. 

Some Remarks on Rate Laws. Experimentally, formation of metal-loporphyrins has always been followed spectrophotometrically. Due to high extinction coefficients in the visible, the concentration of porphyrin is usually kept below 10 M. Thus, it is possible to choose total concentrations of metal species, [M]j, in considerable excess of total porphyrin [P]j. In these cases first-order dependence according to... 

ALA plus DP acted synergistically as herbicides, despite the fact that there was generally only an additive effect on total porphyrin accumulation (Table I). These results indicate one or more of the following (a) one of the earlier chlorophyll intermediates (MgPPIXME or PPIX) is more herbicidal than PChlide,... 

Special laboratory Urine 24 h total porphyrins grossly and constantly elevated ... 

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