Total morphology score

Rodent whole embryo culture has been routinely used over the past three decades. Alone with the culture method, a score system developed by Brown and Fabro, called the total morphology score (TMS) system, is commonly used to evaluate the embryos (2). This method evaluates six developmental stages of a variety of... 

The rodent WEC test is the unique ex vivo test that allows to investigate the chemical effects during organogenesis in a whole-mammalian embryo. It requires gestation day 10-12 rat embryos that are exposed to test chemicals and monitored for a range of well-defined morphological endpoints to derive a total morphological score. Besides this score also malformations and sizes of the whole conceptus and the yolk sac are taken into account [2], This test is presently used by several research laboratories and industries. 

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