Total body irradiation, TBI

Fig. 1. Hypothetical kinetics of depletion of bone marrow (BM) stem cells following exposure to a lethal total-body irradiation (TBI) of 10 Gy (1000 rad) of...

Wenz F, Steinvorth S, Lohr F, et al Prospective evaluation of delayed central nervous system (CNS) toxicity of hyperfractionated total body irradiation (TBI). Int J Radiat Oncol Biol Phys 48 1497-1501, 2000 Yamada M, Kodama K, Wong FL The long-term psychological sequelae of atomic-bomb survivors in Hiroshima and Nagasaki, in The Medical Basis for Radiation-Accident Preparedness, III The Psychological Perspective. Edited by Ricks RC, Berger ME, O Hara FM Jr. New York, Elsevier, 1991, pp 155-163... 

An incidence of 5%-25% even after total body irradiation (TBI) is reported, which is applied for conditioning therapy prior to bone-marrow or stem cell transplantation (Monson et al. 1998). One problem in detecting radiation toxicity is the time delay after radiation, which is approximately 3 weeks, but can also occur several months later (Monson et al. 1998 Oikonomou and Hansell 2002). 

TBI Total-body irradiation, traumatic brain injury yr Year... 

MHC major histocompatibility complex MLC mixed lymphocyte culture MLR mixed lymphocyte reaction MUD matched unrelated donor NMDP National Marrow Donor Program NMT nonmyeloablative transplant PBPC peripheral blood progenitor cell PBSC peripheral blood stem cell PCR polymerase chain reaction TBI total body irradiation UCB umbilical cord blood VOD (hepatic) veno-occlusive disease... 

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