Topographical considerations

In the past, abundant resources made it possible to use cold water on a once-through basis. Where topographical considerations were accounted for, large ponds, lakes or canals were used to contain, cool and recirculate or discharge process waters. To facilitate cooling and reduce land requirements, spray systems were often employed to aerate the water in the ponds. 

V. J. Hruby, P. M. Balse, Conformational and topographical considerations in designing agonist peptidomimetics from peptide leads. Curr. Med. Chem. 2000, 7, 945-970. 

Hruby VJ, Nikiforovich GV (1991) The Ramachandran Plot and Beyond Conformational and Topographical Considerations in the Design of Peptides and Proteins. In Molecular Conformation and Biological Interactions (Balaram P and Ramasehan S, eds) pp 429 45. Bangalore Indian Academy of Sciences. 

Figure 2.9. Conversion of (2jS,3i2)TMT -c[DPDPE] into a nonpeptide peptide mimetic based on topographical considerations.

For all these reasons, the loose definition of RP s is certainly interesting. But claiming that it is a cure-all, would be a real mistake for certain purposes (in particular for small systems when either dynamical or topographical considerations are important), the steepest-descent definitions can well be more appropriate ... 

Bracci, S. 2009. Growth and Development of Ancient Near Eastern Towns of the Diyala Region. Some Topographical Considerations. Zeitschrift fur Orient-Archaeologe 2 8-35. 

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