2, 4-Toluene diisocyanate precautions

Because of its high toxicity, carcinogenicity, and ability to cause sensitization, toluene diisocyanate should be handled using the "basic prudent practices" of Chapter 5.C, supplemented by the additional precautions for work with compounds of high toxicity (Chapter 5.D). In particular, work with TDI should be conducted in a fume hood to prevent exposure by inhalation, and splash goggles and impermeable gloves should be worn at all times to prevent eye and skin contact. 

Example 5. Toluene diisocyanate (TDI) has an LD50 (rat, oral) = 2060 mg/kg, which places it in HC 5 with regard to ingested toxicity. However, the LC50 (various animals) = 0.06-0.35 mg/L (4 h), which places it in HC 1 for inhaled toxicity. Furthermore, it is described as a powerful irritant to eyes, skin, and the respiratory tract, which places it in HC 1 for skin corrosive, respiratory sensitizer, and eye damage. Clearly, many precautions must be taken when working with TDI. 

TDI has a sharp, pungent, sweetish odor. Its vapors are toxic. Certain precautions are necessary when handling or using toluene diisocyanate. Before using TDI, obtain and study ARCO Chemical s Material Safety Data Sheet (MSDS) and product literature. For more information, see TDI Safety and Handling below. 

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