Tolerance, drug hallucinogens

N,N-DMT DMT (N,N-dimethyltryptamine) is one of the most hallucinogenic compounds known. DMT is not active orally (unless in the form of an ayahuasca brew), but must be smoked in it s freebase form to experience its effects. (DMT can be taken orally when mixed with a MAOIs, but this is not recommended for the first time user.) The body quickly builds a tolerance for the drug. Your DMT dose must be taken within 60 seconds. Any more of the drug after this first minute will not enhance the experience. It is recommended to give at least one hour before attempting another DMT trip. 

LSD is very potent and produces both CNS and peripheral effects. Because of the rapid tolerance produced with these drugs, the typical abuser does not use the drug on a daily basis. Generally, an hallucinogen is abused approximately once per month. 

Hallucinogenic drugs like LSD are not reinforcing In animals, In that they will not self-admlnister these drugs. SNA, however, Is self-administered In large quantities by monkeys equipped with intravenous catheters when access is unlimited. Tolerance of the acute... 

These CNS stimulants have sometimes been referred to as hallucinogens but are more appropriately referred to as psychomimetics because few, if any, cause an absence of reality, that is, a hallucination. Psychomimetics distort or heighten sensory input, produce dream-like states, and can be psychologically addictive. There is no consistent evidence that they can produce tolerance or physical dependence. This is not to imply that these drugs are innocuous. The distortions of reality can lead to panic, anxiety, lack of concentration, and psychotic states to say the least. 

LSD is not considered an addictive drug. When people use it regularly, however, they may become psychologically dependent on it. In addition, people may develop a tolerance to the drug and will need to consume larger quantities of it in order to experience the same hallucinogenic effects that they used to achieve with small doses. 

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