Tolbutamide drug interactions

Anderaen LA Ibtqnofen and tolbutamide drug interaction study. BrJ Clin Pract (1980) 34 (Siq>pl6), 10-12. 

Tannenbaum H, Anderson LG, Soeldner JS. Phenylbutazone-tolbutamide drug interaction N EnglJMed 91A) 290, 344. 

Drug Interactions Increased prothrombin time after warfarin administration Phenytoin Cyclosporine Tolbutamide Tacrolimus Glyburide Glipizide Rifampin Cisapride Terfenadine Astemizole Theophylline ... 

Dixit AA, Rao YM. Pharmacokinetic interaction between diltiazem and tolbutamide. Drug Metabol Drug Interact 1999 15(4) 269-77. 

Komatsu K, Ito K, Nakajima Y, Kanamitsu S, Imaoka S, Funae Y, Green CE, Tyson CA, Shimada N, Sugiyama Y. Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments. Drug Metab Dispos 2000 28(4) 475-81. 

Sugita O, Sawada Y, Sugiyama Y, Iga T, Hanano M. 1982. Physiologically based pharmacokinetics of drug-drug interaction a study of tolbutamide-sulfonamide interaction in rats. J Pharmacokinet Biopharm 10 297-316. 

LEFLUNOMIDE ANTIDIABETIC DRUGS -TOLBUTAMIDE Possible T effect of tolbutamide Uncertain Monitor blood sugar closely. Watch for and warn patients about symptoms of hypoglycaemia - For signs and symptoms of hypoglycaemia, see Clinical Features of Some Adverse Drug Interactions, Hypoglycaemia... 

Drug Interactions. Enzyme inducers, such as carbamazepine and phenytoin, increase tiagabine clearance and decrease the half-life. Food decreases the rate but not the extent of absorption. Tiagabine is displaced from protein by naproxen, salicylates, and valproate. However, tiagabine does not displace phenytoin, valproic acid, amitrypty-line, tolbutamide, or warfarin. ... 

DRUG INTERACTIONS Chloramphenicol inhibits hepatic CYPs and thereby prolongs the half-hves of CYP substrates, including coumadin, phenytoin, chlorpropamide, HIV protease inhibitors, rifabutin, and tolbutamide. Severe toxicity and death have occurred due to these drug interactions. Concurrent administration ofphenobarbital or rifampin, which potently induce CYPs, shortens chloramphenicors t j and may result in subtherapeutic drug concentrations. 

Drug interactions Chloramphenicol inhibits the metabolism of several drugs, including phenytoin, coumarins, and tolbutamide. 

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