Tolbutamide Diphenylhydantoin

Blood dyscrasias, mostly dose independent, are among the most important allergic-type adverse reactions to drugs. Aplastic anemia is a serious but rare (presumably) idiosyncratic reaction. It has been reported in association with chloramphenicol, quinacrine, phenylbutazone, mephenytoin, gold compounds, and potassium chlorate. Hemolytic anemia, thrombocytopenia, and agranulocytosis may result from an unusual, acquired sensitivity to a variety of widely used drugs including aminopyrine, phenylbutazone, phenothiazines, propylthiouracil, diphenylhydantoin, penicillins, chloramphenicol, sulfisoxazole, and tolbutamide. 

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Skovsted L, Kristensen M, Hansen M, Siersbsek-Nielsen K. The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism. Acta Med Scand (1976) 199,513-15. 

Svendsen TL, Kristensen MB, Hansen JM, SkovstedL. The influence of disulfiram on the half life and metabolic clearance rate of diphenylhydantoin and tolbutamide in man. Eur J Clin Phamacol( 976) 9,439-41. 

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Wesseling H, Thurkow I and Mulder GJ. Effect of sulphoitylureas (tolazamide, tolbutamide and chlorpropamide) on the metabolism of diphenylhydantoin in the rat. Biochem Pharmacol (1973) 22, 3033-40. 

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