Toggle switch

A remarkable feature of phosphazene polymers of types (1) and (2) is that appropriate substituents (which are readily attached) can be used as toggle switches to turn several properties, such as hydrolytic stabiHty and electrical conductivity, on and off (1). 

Fig. 6. The rotamer toggle switch. Agonist binding leads to changes in the rotameric states of aromatic amino acids in TM6 resulting in a change in the angle of the helical kink formed by the highly conserved Pro2886 5. ...

This technology allows the sensitive analysis of small conformational changes and will ultimately allow an understanding of the receptor activation mechanism. These studies have shown two distinct switch mechanisms in the / -adrenergic receptor, both located in the third intracellular loop and the cytoplasmic end of transmembrane helix VI an ionic lock mechanism that involves an interaction of the cytoplasmic ends of helix VI and helix III (and is reported by a label in position 271 of the receptor), and a rotamer toggle switch mechanism that is reported by a label in position 265 (Yao et al, 2006). 

Elling, C. E., Frimurer, T. M., Gerlach, L., Jorgensen, R., Holst, B. and Schwartz, T. W. (2006). Metal ion site engineering indicates a global toggle switch model for seven-transmembrane receptor activation. J. Biol. Chem. 281, 17337-17346. 

The toggle switch is flipped on. The fuze is now armed and the delay period has started. (The delay is determined by the time required for the seeds to expand sufficiently to bring the contacts together. 

A "momentary" switch may be used in place of the toggle switch. This is a push button that breaks the circuit only while it is depressed. This is more convenient than the toggle switch, but any type of switch will work. [My original test model of this unit used a sliding switch from one of my son s old toy phaser guns.) Also included are a power lamp and detonator jack so the device may be safely field-tested. This is important because most timers must be... 

The tilt-fuzed bomb is placed under the floor of the car, approximately 12 inches in from the door and 6 to 8 inches forward of the door jamb. After the det is unplugged, the toggle switch is flipped on. If the red light comes on, it means there is power to the det jack. If the detonator were plugged in at this point, the bomb... 

Gardner TS, Cantor CR, Collins JJ (2000) Construction of a genetic toggle switch in Escherichia coli. Nature 403 339-342... 

K. Y. Kim and J. Wang. Potential energy landscape and robustness of a gene regulatory network toggle switch. PLoS Comp. Biol., 3 e60, 2007. 

One toggle switch for 12 volts.(Auto supply store or junkyard)... 

A. The toggle switch and second push switch are the controls and are mounted at your fire control center. In the drawing I show them Just under the rifle,but they can be whatever distance you want (such as on the dash of the car). 

---