Tobacco tetanus

Tetanus toxin fragment C Tobacco leaves Systemic IgG and local IgA responses. Immuno- -genic in mice when administered nasally. 113... 

Another vaccine protein that has recently been produced in tobacco chloroplasts is the Fragment C domain of tetanus toxin (TetC). TetC is a nontoxic 47 kDa polypeptide that can induce an immune response upon... 

Natural nicotine is the levo variety. Physiologically the alkaloid affects both the central and peripheral nerves and increases the activity of the secreting glands. In more than minimum doses it is a poison. It is not used to any extent in medicine though recently it has been suggested as a hypodermic in cases of tetanus. The salicylic acid salt is also used somewhat for skin diseases. Tobacco extracts and also powdered tobacco are used as insecticides, their value depending upon the amount of nicotine present. I... 

Reaction of aldehydes with the indole NH group of tryptophan in proteins has been reported in tetanus toxin (251) and tobacco mosaic virus (26). In the latter instance, the Folin s phenol reagent color value decreased as the reaction with formaldehyde proceeded, and increased with removal of the aldehyde by dialysis in dilute acid. Indole, pure tryptophan, and glycyl tryptophan behaved in a similar manner, but not t3unsine nor glycyltyrosine. Benzaldehyde, acetaldehyde, propionalde-hyde, and butyraldehyde were also used in this work with similar effect. Reversal of formaldehyde inactivation of tobacco mosuc virus could not be confirmed (356). It was also claipaed that the drop in phenol color could not be correlated with a decrease in virus infectivity. 

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