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TNF a receptor

Guo, T.L., Mudzinski, S.P. and Lawrence, D.A., The heavy metal lead modulates the expression of both TNF-a and TNF-a receptors in lipopolysaccharide-activated human peripheral blood mononuclear cells, J. Leuk. Biol. 59, 932, 1996. [Pg.222]

TNF-a is a cytokine produced by T cells and mast cells. TNF-a is involved in the gut inflammatory process in Crohn disease, where treatment with soluble TNF-a receptor and anti-TNF-a antibodies and soluble TNF-a receptor has the highest... [Pg.182]

Understanding the role of Fc and FcRN has allowed engineering of hybrid molecules that take advantage of Fc-dependent plasma half-life extension in designing fusion proteins intended for therapeutic use. An example is the construct of the TNF receptor-Fc fusion protein, which results in a significant increase in the half-life of the TNF receptor [20-22]. Enbrel, a recombinant TNF-a-receptor-Fc fusion protein, has provided effective treatment for rheumatoid arthritis patients. [Pg.281]

Also, research has recently indicated that TNF-a is involved in the cytotoxicity, and knockout mice studies have shown that absence of the two TNF-a receptors completely removes sensitivity to MPTP. [Pg.342]

Etanercept is a genetically engineered protein that is soluble TNF-a receptor. Its molecular weight is 75kDa. It binds to TNF-a. It is used for the treatment of rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis. Structurally, two TNF-a receptors are linked to an Fc portion of an... [Pg.51]

IgGl molecule. Consequently, an artificial antibody is constituted with two Fab sites, which are soluble human 75-kDa TNF-a receptors. It competitively inhibits the binding of TNF molecules to the TNF receptor sites. The binding of etaner-cept to TNF renders the bound TNF biologically inactive, resulting in the reduction of the inflammatory activity. The most frequent adverse side effects are injection site reactions, infections and headache and malignancies are rare. Etanercept is not recommended for patients with serious infections or sepsis and does not appear to result in the reactivation of tuberculosis. [Pg.52]

Fig. 8.1 A schematic diagram illustrating the involvement of NF-k I in gpl20, ROS, NO, PG, IL-1/3 and TNF-a-mediated neurotoxicity. NMDA-R, N-Methyl-D-aspartate receptor, cPLA2, cytosolic phospholipase A2 lyso-PtdCho, lysophosphatidylcholine AA, arachidonic acid cAMP, cyclic adenosine monophosphate PKA, protein kinase A TNF-a, tumor necrosis factor-a TNF-a-R, TNF-a-receptor IL-1/8, interleukin-1 /3 IL-l/i-R, IL-1/8-receptor, IL-6, interleukin-6 MARK, mitogen-activated protein kinase NO, nitric oxide PG, prostaglandins EP-R, prostaglandin receptors NF-kB, nuclear factor-icB NF-kB-RE, nuclear factor-/cB-response element I/cB, inhibitory subunit of NF-icB HIV-1, human immunodeficiency virus type 1 gpl20, HIV-1 coat glycoprotein COX-2, cyclooxygenase-2 iNOS, inducible nitric oxide synthase SPLA2, secretory phospholipase A2 SOD, superoxide dismutase MMP, matrix metalloproteinase and VCAM-1, vascular adhesion molecule-1... Fig. 8.1 A schematic diagram illustrating the involvement of NF-k I in gpl20, ROS, NO, PG, IL-1/3 and TNF-a-mediated neurotoxicity. NMDA-R, N-Methyl-D-aspartate receptor, cPLA2, cytosolic phospholipase A2 lyso-PtdCho, lysophosphatidylcholine AA, arachidonic acid cAMP, cyclic adenosine monophosphate PKA, protein kinase A TNF-a, tumor necrosis factor-a TNF-a-R, TNF-a-receptor IL-1/8, interleukin-1 /3 IL-l/i-R, IL-1/8-receptor, IL-6, interleukin-6 MARK, mitogen-activated protein kinase NO, nitric oxide PG, prostaglandins EP-R, prostaglandin receptors NF-kB, nuclear factor-icB NF-kB-RE, nuclear factor-/cB-response element I/cB, inhibitory subunit of NF-icB HIV-1, human immunodeficiency virus type 1 gpl20, HIV-1 coat glycoprotein COX-2, cyclooxygenase-2 iNOS, inducible nitric oxide synthase SPLA2, secretory phospholipase A2 SOD, superoxide dismutase MMP, matrix metalloproteinase and VCAM-1, vascular adhesion molecule-1...
Infliximab Chimeric IgGl TNF-ad Soluble substance TNF-a receptor 1 ... [Pg.89]

These drugs fall into two types soluble TNF-a receptors, such as etanercept, and humanised monoclonal antibodies against TNF-a. Etanercept is a fusion... [Pg.335]

TNF-a receptor inhibitors consisting of indole derivatives, (VI), were prepared by Cirillo (7) and used in the treatment of rheumatoid arthritis. [Pg.158]

Liu J-Y, Brass DM, Hoyle GW, et al. 1998. TNF-a receptor knockout mice are protected from the fibroproliferative effects of inhaled asbestos fibers. Am J Pathol 153(6) 1839-1847. [Pg.296]

Recombinant human soluble tumor necrosis factor-alpha (TNF-a) receptor protein Enbrel (etanercept) Autoimmune diseases Amgen-Wyeth 4.5... [Pg.298]

See other pages where TNF a receptor is mentioned: [Pg.163]    [Pg.183]    [Pg.426]    [Pg.384]    [Pg.71]    [Pg.372]    [Pg.327]    [Pg.414]    [Pg.473]    [Pg.40]    [Pg.114]    [Pg.135]    [Pg.259]    [Pg.163]    [Pg.336]    [Pg.333]    [Pg.336]    [Pg.305]    [Pg.146]    [Pg.350]    [Pg.515]    [Pg.648]    [Pg.188]    [Pg.188]    [Pg.350]    [Pg.515]    [Pg.648]    [Pg.692]    [Pg.873]    [Pg.12]    [Pg.15]    [Pg.645]    [Pg.249]    [Pg.1779]    [Pg.524]   
See also in sourсe #XX -- [ Pg.163 ]

See also in sourсe #XX -- [ Pg.163 ]



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