Tissue engineering biophysical cues

To repair or replace the damaged cartilage with tissue-engineering approaches, it is important to consider the local structure of the cartilage for appropriate biomechanical functions (Wilson et al 2006). The solution of this complex problem should be based upon a combinatory effort of proper material selection, adequate cell sourcing, and incorporation of biochemical/biophysical cues (Vinatier et al., 2009). 

This review outlined the progress over the past few decades in tissue engineering strategies that use hydrogels to treat musculoskeletal tissue loss. Significant advancements have been made in the design and development of hydrogel scaffolds which incorporate many of the required biochemical and biophysical cues for tissue development. Novel methods have been de-... 

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