Time-dependent reversibility

An adjacent tnfluoromethyl group sharply increases the electrophilic character of the carbonyl carbon Compounds that readily form hydrates and hemiacetals show a time-dependent reversible mhibition of the en yme acetylcholinesterase (equation 2), in which the tight complex makes inhibition only partially reversible [75] In comparison with a nonfluormated analogue, several aliphatic ketones flanked by CFj and CF2 groups, are exceptionally potent reversible inhibitors of acetylcholinesterase, as documented by companson of inhibition constants shown in equation 3 [16 ... 

Slow, time-dependent, reversible inhibitors of COX-1 and COX-2. E.g. indomethacin and flurbiprofen seem to act by ionic interactions between their carboxylic acid function and the arginine residue of the enzyme. This effect seems to influence the helix D of the protein followed by a significant loss of flexibility in the enzyme protein. 

Gardenas, M. and Matis, J., On the time-dependent reversible stochastic compartmental model. II. A class of n-compartment systems, Bulletin of Mathematical Biology, Vol. 37, 1975, pp. 555-564. 

The two components of calcium channel block, a time-dependent reversible block and a time-independent irreversible block, suggest two separate sites of action of tetramethrin in calcium channels. However, type II pyrethroids modify sodium channels only. This difference in action between type I pyrethroids and a-cyano type II pyrethroids may be partially responsible for the different symptoms of poisoning in animals. 

Time-dependent reversibility of prothrombin and fibrinogen adsorption. The equilibrium binding constant of prothrombin on DOPS bilayers can be calculated both from equilibrium measurements and dynamic measurements (K =k indicating that this system is... 

The recorded images of swimming cells are analyzed using the EVIOOO computerized (66) cell-tracking system to extract the time-dependent reversal frequency of the cells (Fig. 5 see for example ref. 67). 

As mentioned earlier, the DMTA technique measures molecular motion in adhesives, and not heat changes as with DSC. Many adhesives exhibit time-dependent, reversible viscoelastic properties in deformation. Hence a viscoelactic material can be characterized by measuring its elastic modulus as a function of temperature. The modulus depends both on the method and the time of measurement. Dynamic mechanical tests are characterized by application of a small stress in a time-varying periodic or sinusoidal fashion. For viscoelastic materials when a sinusoidal deformation is applied, the stress is not in phase with displacement. A complex tensile modulus E ) or shear modulus (G ) can be obtained ... 

Time-dependent reversible processes are invariant with regard to the algebraic sign of the time. 

Nasal suspensions can be characterised by thixotropic properties [41]. Nasal sprays containing triamcinolone acetonide or mometasone furoate showed time-dependent, reversible loss of viscosity under shear (shaking or spraying,) flowing more freely. Recovery of viscosity after application is likely to inhibit suspension flowing out from the nasal cavity [42, 43]. 

Our observations suggest that [ H]chloroadenosine, an adenosine receptor agonist, identifies binding sites in human placenta with characteristics of the high affinity, adenosine receptor. The binding is time dependent, reversible and saturable. The potency series of adenosine receptor methylxanthine antagonists in displacing C Hi chloroadenosine is appropriate. 

The drop-volume method allows measurements of solutions without further dilution, i.e. irreversibility and/or time-dependent reversibility at dilution of the complexes due to total concentration of amphiphile is avoided. In addition, adsorption to the surface created during formation of the droplet might be seen as analogous to adsorption to surfaces created in foams and emulsions, for example. 

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