Tiludronate Aspirin

Drugs that may interact with alendronate include ranitidine and aspirin. Drugs that may interact with tiludronate include aspirin and indomethacin. Calcium... 

Paget s disease PO 400 mg once a day for 3 mo. Must takewith6-8oz plain water. Do not give within 2 hr of food intake. Avoid giving aspirin, calcium supplements, mineral supplements, or antacids within 2 hr of tiludronate administration. 

Clinically important, potentially hazardous interactions with aldesleukin, aspirin, diflunisal, diuretics, methotrexate, NSAIDs, prednisolone, prednisone, sermorelin, tiludronate, torsemide, triamterene, urokinase... 

Single-dose studies in 12 healthy subjects found that diclofenac 25 mg and aspirin 600 mg had no significant effect on the pharmacokinetics of tiludronate. On the other hand, indometacin 50 mg increased the maximum serum concentration and the AUC of tiludronate about twofold when these drugs were taken together, but not when they were given 2 hours apart." For this reason the manufacturers advise that indometacin and tiludronate should be given 2 hours apart. 

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