Tied proximities

Latentiation of ampicillin can also be achieved by tying up the proximate amino and amide functions as an acetone aminal. Inclusion of acetone in the reaction mixture allows 6-APA to be condensed directly with the acid chloride from 24. There is thus obtained directly the prodrug hetacillin (34). Although this compound has little antibiotic activity in its own right, it hydrolyzes to ampicillin in the body. The p-hydroxy derivative amoxycillin (35) shows somewhat better oral activity. A similar sequence using formaldehyde gives metampicillin (36). °... 

Shimonishi and coworkers observed that the residues in the second P turn are proximal to the receptor in the binding of enterotoxin [12]. This ties in with the observation that the toxicity of the protein too is unaffected by changing specific residues in the first and the third / turns, while the activity was considerably affected when similar mutations were effected in the residues of the second /3 turn. In order to relate to these biochemical studies, we have classified the hydration layer of 1ETN into three regions, based on their proximity to each of the three 6 turns. 

The fourth element of negligence is proximate cause, sometimes referred to as legal cause, which serves to tie together the negligent act (or failure to act) and the resulting injury. 

Hazardous waste sites release mixtures of solvents into the air and heavy metals, pesticides, and other organic compounds into surface and ground-waters. Several studies in different geographic settings have tied maternal residential proximity to increased teratogenic risks. These studies include the following ... 

Samples of the feed to the densifier were supplied to ASTM E-38.01 as the material for round-robin analysis of RDF proximate and ultimate fuel properties. The samples were generated on three separate occasions over a period of 17 months by diverting the output from the secondary shredder. A pile of approximately 100 kg was repeatedly coned and quartered and aliquots of 1 to 2 kg were packaged in double polyethylene bags and tied. Several bags of each sample were sent to participating laboratories. 

Bandyopadhyay et al. (2005) observed that the residues in the second (3 turn are proximal to the receptor in the binding of lETN protein. This ties in... 

MacCuish J. Nicolaou C. MacCuish NE. Ties in proximity and clustering compounds. J Chem Inf Comput Sci 2001 41 134-146. 

As shown in Figme 9.22A for the control site, in this model the abdominal wall is scraped until it bleeds a loop of proximal intestine is punctured until it bleeds and exudes feces a loose suture brings the two injured surfaces into proximity and is tied off in such a manner... 

Referring back to the mosaic tile model in Section 2.5, over time some of the rubber bands from particle to particle wrap around the particles instead. This action displaces the menhaden fish oil which then acts like a Type II plasticizer to lubricate the system. The end result of this interaction follows logically out of the mosaic tile model. Fewer rubber band ties between particles result in a weaker tape. More olive oil, or in this case fish oil, in the matrix results in greater deformation under its own weight and higher plastic deformation. As aging time increases with both PVB and MFO in proximity to the particle surface, the tape becomes weaker and floppier and can even discolor the drying surface of the tape. 

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